ArticleClinical kidney journal2021
Acute kidney injury following prophylactic flucloxacillin and gentamicin in primary hip and knee arthroplasty.
Article in Clinical kidney journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 8 citations in OpenAlex.
- Risk Factors for Nephrotoxicity in Methicillin-Resistant Staphylococcus aureus Bacteraemia: A Post Hoc Analysis of the CAMERA2 Trial.Clinical drug investigation · 2023Trial
- Cefazolin Versus Flucloxacillin for Methicillin-SusceptibleAntibiotics (Basel, Switzerland) · 2026Article
- A review of the randomized clinical trial results from the Staphylococcus aureus network adaptive platform (SNAP) meticillin-susceptible (MSSA) and penicillin-susceptible (PSSA) domains and CloCeBa.The Journal of antimicrobial chemotherapy · 2026Review
- Effect of potential risk factors on renal functions in simultaneous bilateral total knee arthroplasty.Frontiers in surgery · 2024Article
- Reducing incidence of postoperative acute kidney injury in trauma and orthopaedics patients: a quality improvement project.BMJ open quality · 2023Article
- International Survey of Practice for Prophylactic Systemic Antibiotic Therapy in Hip and Knee Arthroplasty.Antibiotics (Basel, Switzerland) · 2022Article
- Letter to the editor: Flucloxacillin-induced acute kidney injury in a critically ill patient.Saudi journal of anaesthesiaArticle
- Additional doses of prophylactic antibiotics post-arthroplasty: Are there any benefits?Journal of perioperative practiceReview
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFollowing concerns regarding the emergence of
methodsWe examined the incidence of AKI as defined by Kidney Disease: Improving Global Outcomes criteria in 1588 patients undergoing primary hip or knee arthroplasty from January 2010 to January 2015. Patients received the following prophylactic antibiotic regimes: 8 g flucloxacillin in four divided doses and SD gentamicin 1.5 mg/kg ideal body weight (IBW; maximum dose 120 mg;
resultsThe incidence of AKI was as follows: flucloxacillin and gentamicin (13%); flucloxacillin alone (8.5%); SD cefuroxime (2%); TD cefuroxime (0.5%); and teicoplanin and gentamicin (3%). Of the six patients who developed Stage 3 AKI, all were in the flucloxacillin and gentamicin group. The odds ratio for the development of AKI derived from a binary logistic regression model was highest in the flucloxacillin and gentamicin group [7.79 (95% confidence interval 3.54-17.14), P < 0.0001].
conclusionsOur findings suggest that the use of prophylactic high-dose flucloxacillin and gentamicin should be used with caution in patients undergoing primary hip or knee arthroplasty without a clear advantage in reducing surgical site infections given the association with increased rates of AKI.
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