ArticleAmerican journal of translational research2021
Association between the platelet to lymphocyte ratio, neutrophil to lymphocyte ratio and axillary lymph node metastasis in cT1N0 breast cancer patients.
Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- The evidence for the use of peripheral blood indices in the diagnosis of breast cancer.The Journal of international medical research · 2026Review
- Assessing the clinical utility of pre-operative neutrophil-lymphocyte ratio as a predictor of clinicopathological parameters in patients being treated for primary breast cancer.Breast cancer research and treatment · 2025Article
- Article
- New Insight for Axillary De-Escalation in Breast Cancer Surgery: "SoFT Study" Retrospective Analysis.Current oncology (Toronto, Ont.) · 2024Article
- Predictive efficacy of the preoperative neutrophil-lymphocyte ratio in lymph node metastasis of cN0 hormone receptor-positive breast cancer.Scientific reports · 2024Article
- A nomogram for intraoperatively predicting non-sentinel lymph node metastases in early breast cancer patients with positive sentinel lymph nodes.Gland surgery · 2023Article
- Neutrophil/lymphocyte ratio predicts lymph node metastasis in patients with gastric cancer.American journal of translational research · 2023Article
- Preoperative Breast Immune Prognostic Index as Prognostic Factor Predicts the Clinical Outcomes of Breast Cancer Patients Receiving Neoadjuvant Chemotherapy.Frontiers in immunology · 2022Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the relationship between platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR) and axillary lymph node metastasis in cT1N0 breast cancer patients.
methodsThe clinicopathological data of 154 patients with cT1N0 breast cancer from January 2015 to June 2020 were retrospectively analyzed. All patients underwent sentinel lymph node (SLN) biopsy. The differences of PLR and NLR levels among groups with different clinicopathological factors (age, tumor size, ER, PR, HER-2, Ki67, p53 expression levels, vascular tumor thrombus and SLN metastasis) were compared. The relationship between clinicopathological factors and metastasis of SLN and non-SLN was analyzed.
resultsThere were 32 patients with SLN metastasis. The cut-off values of PLR and NLR for the whole group were 142.91 and 2.84. The PLR level was higher in patients with vascular tumor thrombus and SLN metastasis (P<0.05), and the NLR level was higher in patients with P53 negative and SLN metastasis groups (P<0.05). According to univariate analysis, there were significant differences in SLN metastasis among different tumor sizes, vascular tumor thrombus states, PLR and NLR levels (P<0.05), but there was no significant difference in SLN metastasis among patients with different ages, ER, PR, HER-2, Ki67, p53 expression groups (P>0.05). According to multivariate analysis, the risk of SLN metastasis in patients with vascular tumor thrombus was higher than that in patients without vascular tumor thrombus (P<0.05). The risk of SLN metastasis in patients with high level of PLR was higher than that in patients with low level of PLR (P<0.05). The difference was not significant in SLN metastasis status among patients with different ages and ER, PR, HER-2, Ki67, p53 expression and NLR level (P>0.05).
conclusionHigh level of PLR and vascular tumor thrombus are the risk factors for SLN metastasis.
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Identifiers
33841711PMC8014375W3152830188What OpenQuestion holds
Registered trials
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