Evidence map›Paper›PMID 33841679›Full record

ArticleAmerican journal of translational research2021

General anesthesia versus monitored anesthesia care during endovascular therapy for vertebrobasilar stroke.

Guangjun Hu, Zhen Shi, Bixi Li, Weidong Shao, Bo Xu

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05082896 (Multicentre ObseRvational Study in Posterior mecHanical thrombEctomy), which is not on this map. Cited by 17 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 8 pooled it
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05082896 completednot on this map

Multicentre ObseRvational Study in Posterior mecHanical thrombEctomy: conscioUs Sedation vs General aneSthesia: MORPHEUS STROKE REGISTRY

Typeobservational_patient_registrySponsorInstitut d'Investigació Biomèdica de Girona Dr. Josep TruetaRan2021 to 2023Enrolled453ConditionsMechanical Thrombectomy, General Anesthesia, Conscious Sedation, Posterior CirculationArmsType of anesthesia choice
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 8 syntheses or guidelines pooled it, 23 citations in OpenAlex.

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  8. Type of anaesthesia for acute ischaemic stroke endovascular treatment.The Cochrane database of systematic reviews · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Guangjun HuThe First Clinical College of Southern Medical University Guangzhou, Guangdong Province, China.
Zhen ShiDepartment of Pain Treatment, Hubei Provincial Hospital of Traditional Chinese Medicine Wuhan, Hubei Province, China.
Bixi LiDepartment of Anesthesiology, General Hospital of The Central Theater Command of The Chinese PLA Wuhan, Hubei Province, China.
Weidong ShaoDepartment of Anesthesiology, General Hospital of The Southern Theater Command of The Chinese PLA Guangzhou, Guangdong Province, China.
Bo XuThe First Clinical College of Southern Medical University Guangzhou, Guangdong Province, China.
General Hospital of Guangzhou Military Command · CNCentral Hospital of Wuhan · CNHubei Provincial Hospital of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe objective is to compare the effect of general anesthesia (GA) and monitored anesthesia care (MAC) on clinical outcomes in patients with endovascular therapy for vertebrobasilar occlusion stroke.

methods139 patients undergoing endovascular therapy for vertebrobasilar stroke, were recruited. The patients were randomized into GA group and MAC group (about 1:1 ratio). GA group received general anesthesia and MAC group received monitored anesthesia care during endovascular therapy. The primary outcome measure was the shift in the degree of disability among the 2 groups as measured by the modified Rankin scale score (mRS) at 90 days (80-100 days). Secondary end points included infarct volume and related complications.

resultsThe patients were assigned randomly (about 1:1 allocation) to GA group (n=72) and MAC group (n=67). The primary outcome of functional independence measured by 90-day mRS score was not significantly different between the 2 groups (median (IQR), 2 (1-3) vs. 3 (1-4); P=0.316). Final infarct volume was smaller in the GA group than in the MAC group (median (IQR), 27.60 (13.75-83.52) vs. 33.60 (26.85-92.95); P=0.045). There were no differences with statistical significance in rates of successful reperfusion (modified Thrombolysis in Cerebral Ischemia (mTICI) 2b-3) between 2 groups (73.61% vs. 76.12%; P=0.734). Early neurological outcomes measured by the 24-hour National Institutes of Health Stroke Scale scores (NIHSS) showed that 11 (interquartile range (IQR), 3-22) in GA group and 11 (interquartile range (IQR), 7-25) in MAC group, but were not statistically significant. There was no statistical difference in postoperative complications between the two groups.

conclusionFor patients who underwent endovascular therapy for vertebrobasilar occlusion strok caused by occlusions in the posterior circulation, MAC appears to be as effective as GA. However, MAC is associated with bigger final infarct volume. Future studies are warranted to confirm our findings.

Indexed as

endovascular therapyGeneral anesthesiamonitored anesthesia carevertebrobasilar stroke

Identifiers

PMID33841679
PMCPMC8014376
OpenAlexW3153399197

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.