ArticleAmerican journal of translational research2021
Dysbiosis of intestinal microbiota in critically ill patients and risk of in-hospital mortality.
Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed, 31 citations in OpenAlex.
- Comparison between the NUTRIC score and modified NUTRIC score to predict hospital mortality in patients undergoing cardiac surgery: A retrospective study.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2026Article
- Maternal microbiota in relation to mortality, culling, and offspring survival in rabbits.Journal of animal science · 2026Article
- Development of a prognostic model for sepsis based on gut microbiota-associated genes and identification of potential targets.Frontiers in medicine · 2026Article
- Adjunctive use ofTranslational gastroenterology and hepatology · 2026Article
- Evaluation and Modulation of Gut Microbiome Dysfunction in Chronically Critically Ill Patients: A Prospective Pilot Study.International journal of molecular sciences · 2025Article
- Dietary tannic acid promotes intestinal clearance of C. albicans by cross-linking hyphal chitosan.PLoS pathogens · 2025Article
- Microbiome-mediated colonization resistance to carbapenem-resistant Klebsiella pneumoniae in ICU patients.NPJ biofilms and microbiomes · 2025Article
- Recent Insights into the Evolving Role of the Gut Microbiome in Critical Care.Critical care clinics · 2025Review
- Article
- Early reduction in gut microbiota diversity in critically ill patients is associated with mortality.Annals of intensive care · 2024Article
- Skin dysbiosis and loss of microbiome site specificity in critically ill patients.Microbiology spectrum · 2024Observational
- A Mendelian Randomization Study: Roles of Gut Microbiota in Sepsis - Who is the Angle?Polish journal of microbiology · 2024Article
- Safety, feasibility, and impact on the gut microbiome of kefir administration in critically ill adults.BMC medicine · 2024Article
- The human gut microbiome in critical illness: disruptions, consequences, and therapeutic frontiers.Journal of critical care · 2024Review
- Antibiotics in anesthesia and critical care.Annals of translational medicine · 2024Review
- Gut mycobiome dysbiosis after sepsis and trauma.Critical care (London, England) · 2024Article
- The role of the peripheral system dysfunction in the pathogenesis of sepsis-associated encephalopathy.Frontiers in microbiology · 2024Review
- Lower gut dysbiosis and mortality in acute critical illness: a systematic review and meta-analysis.Intensive care medicine experimental · 2023Article
- Evaluation of the contribution of gut microbiome dysbiosis to cardiac surgery-associated acute kidney injury by comparative metagenome analysis.Frontiers in microbiology · 2023Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite the essential functions of the intestinal microbiota in human physiology, little research was reported on gut microbiota alterations in intensive care patients. This investigation examined the dysbacteriosis of intestinal flora in critically ill patients and evaluated the prognostic performance of this dysbiosis to predict in-hospital mortality.
methodsA prospective cohort of patients were consecutively recruited in the Intensive Care Units (ICUs) in Guangdong Provincial People's Hospital from March 2017 through October 2017. Acute Physiology and Chronic Health Evaluation (APACHE) II score and Sequential Organ Failure Assessment (SOFA) score were assessed, and fecal samples were taken for examination within 24 hours of ICU admission. The taxonomic composition of the intestinal microbiome was determined using 16S rDNA gene sequencing. Patients were divided into survival and death groups based on hospital outcomes. The two groups were statistically compared using the Wilcoxon test and Metastats analysis. The genera of bacteria showing significantly different abundance between groups were assessed as predictors of in-hospital death. The prognostic value of bacterial abundance alone and in combination with APACHE II or SOFA score was evaluated using the area under the receiver operating characteristic curve (AUROC).
resultsAmong the 61 patients examined, 12 patients (19.7%) died during their hospital stay.
conclusionsDysbiosis of intestinal microbiota with variable degrees of reduction in
Indexed as
Identifiers
33841678PMC8014420W3154350431What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.