Evidence map›Paper›PMID 33841648›Full record

ArticleAmerican journal of translational research2021

Study of effects of anthracycline drugs on myocardial function in breast cancer patients by quantitative analysis of layer-specific strain via 2D-STI technology.

Jing Wu, Yi Ni, Changjiang Gu, Xingxing Gu, Hanzhen Ji, Liqing Li, Jia Zhu, Lihong Huang, Zhiqing Qiao

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jing WuDepartment of Ultrasound, Nantong Third People's Hospital, Nantong University Nantong, Jiangsu Province, China.
Yi NiBreast Surgery, Nantong Third People's Hospital, Nantong University Nantong, Jiangsu Province, China.
Changjiang GuDepartment of Breast Surgery, Affiliated Hospital of Nantong University Nantong, Jiangsu Province, China.
Xingxing GuDepartment of Ultrasound, Nantong Third People's Hospital, Nantong University Nantong, Jiangsu Province, China.
Hanzhen JiLibrary, Nantong Third People's Hospital, Nantong University Nantong, Jiangsu Province, China.
Liqing LiDepartment of Ultrasound, Nantong Third People's Hospital, Nantong University Nantong, Jiangsu Province, China.
Jia ZhuDepartment of Ultrasound, Nantong Third People's Hospital, Nantong University Nantong, Jiangsu Province, China.
Lihong HuangDepartment of Biostatistics, Zhongshan Hospital, Fudan University Shanghai City, China.
Zhiqing QiaoDepartment of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University Shanghai City, China.
Nantong University · CNFudan University · CNRenji Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to explore the value of layer-specific strain analysis by two-dimensional speckle tracking imaging (2D-STI) in the assessment of myocardial toxicity in breast cancer patients receiving anthracycline chemotherapy.

methodsThirty-four breast cancer patients receiving anthracycline chemotherapy were prospectively enrolled. Conventional echocardiography and 2D-STI were evaluated at baseline after the third and sixth cycles of anthracycline chemotherapy. The strains of different layers of left ventricle (LV) including peak systolic longitudinal strain (endo-LS, mid-LS, epi-LS) and circumferential strain (endo-CS, mid-CS, epi-CS) were measured using EchoPAC analysis software. Peak systolic longitudinal strain (MV-LS, PM-LS, AP-LS), circumferential strain (MV-CS, PM-CS, AP-CS) and radial strain (MV-RS, PM-RS, AP-RS) were measured at mitral valve, papillary muscle and apex levels of LV respectively. Global longitudinal strain (GLS), global circumferential strain (GCS), global radial strain (GRS), and left ventricular twist (LVtw) were also analyzed.

resultsThere was no significant difference in the structural and functional parameters of conventional 2D echocardiography in different cycles of anthracycline chemotherapy (P>0.05); layer specific LS and CS in various cycles decreased layer by layer from inside to outside. LS and CS increased from basal segment to apical segment, while RS showed no obvious gradient characteristics; compared with baseline, GLS and LSs (endo-PM, endo-AP, mid-PM, mid-AP and epi-AP) of LV decreased significantly after the third cycle of chemotherapy (P<0.05); LSs (epi-MV and epi-AP) decreased significantly after the sixth cycle of chemotherapy (P<0.05). No significant changes were detected in layer specific CS, RS and LVtw (P>0.05).

conclusionLayer-specific strain analysis by 2D-STI technology can quantitatively analyze global and regional functions of LV. The myocardial toxicity due to anthracycline chemotherapy can be detected by layer-specific LS of LV in early stage, which is great valuable to guiding clinical early intervention and improving prognosis.

Indexed as

anthracycline chemotherapybreast tumorlayer-specific strainleft ventricular functionmalignantSpeckle tracking imagingtwo-dimension

Identifiers

PMID33841648
PMCPMC8014361
OpenAlexW3155700931

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.