Evidence map›Paper›PMID 33841547›Full record

ArticleIranian journal of pharmaceutical research : IJPR2020

Leishmanicidal, Trypanocidal and Antioxidant Activity of Amyrin-Rich Extracts from

João H de Souza, Alexandra Michelon, Fernanda W Banhuk, Izabela V Staffen, Elissandro J Klein, Edson A da Silva, Rafael A Menolli

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Iranian journal of pharmaceutical research : IJPR, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Lupeol Acetate and α-Amyrin Terpenes Activity againstTropical medicine and infectious disease · 2023
    Article
  3. Antileishmanial Activity and In Silico Molecular Docking Studies ofTropical medicine and infectious disease · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

João H de SouzaLaboratory of Applied Immunology, Center of Medical and Pharmaceutical Sciences, Western Parana State University, Cascavel/PR, Brazil.
Alexandra MichelonLaboratory of Applied Immunology, Center of Medical and Pharmaceutical Sciences, Western Parana State University, Cascavel/PR, Brazil.
Fernanda W BanhukLaboratory of Applied Immunology, Center of Medical and Pharmaceutical Sciences, Western Parana State University, Cascavel/PR, Brazil.
Izabela V StaffenLaboratory of Applied Immunology, Center of Medical and Pharmaceutical Sciences, Western Parana State University, Cascavel/PR, Brazil.
Elissandro J KleinLaboratory of Engineering and Environmental Processes, Department of Process and Product Development, State University of Campinas, Campinas/SP, Brazil.
Edson A da SilvaLaboratory of Biotechnological Processes and Separation, Center of Exact and Technological Sciences, Western Parana State University, Toledo/PR, Brazil.
Rafael A MenolliLaboratory of Applied Immunology, Center of Medical and Pharmaceutical Sciences, Western Parana State University, Cascavel/PR, Brazil.
Universidade Estadual do Oeste do Paraná · BRUniversidade Estadual de Campinas (UNICAMP) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThis study aimed to characterize and evaluate leishmanicidal and trypanocidal action as well as cytotoxicity on macrophages and antioxidant ability of extracts, obtained by supercritical CO

methodsLeaves from

resultsThe results of identification showed a great amount of α and β-amyrin in E1 and E2. Both extracts showed growth inhibition of

conclusionsThis is the first study demonstrating the activity of an amyrin rich-extract against microorganisms that cause Chagas disease and leishmaniasis, as well as its antioxidant capacity, justifying further studies for future

Indexed as

Antioxidant activityEugeniaLeishmaniaNatural extractsTriterpenoidsTrypanosoma cruzi

Identifiers

PMID33841547
PMCPMC8019871
OpenAlexW3155891672

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.