Evidence map›Paper›PMID 33841437›Full record

Trial reportFrontiers in immunology2021

Single-Arm, Multicenter Phase I/II Clinical Trial for the Treatment of Envenomings by Massive Africanized Honey Bee Stings Using the Unique Apilic Antivenom.

Alexandre Naime Barbosa, Rui Seabra Ferreira, Francilene Capel Tavares de Carvalho, Fabiana Schuelter-Trevisol, Mônica Bannwart Mendes, Bruna Cavecci Mendonça, José Nixon Batista, Daisson José Trevisol, Leslie Boyer, Jean-Philippe Chippaux and 8 more

Open access · goldAbstract readClinical Trial, Phase IClinical Trial, Phase IIMulticenter Study
In one paragraph

Trial report in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

  1. Translational science at the undergraduate level: awakening talents to overcome the valley of death - case report.The journal of venomous animals and toxins including tropical diseases · 2025
    Article
  2. Article
  3. Clinical complications in envenoming byFrontiers in immunology · 2024
    Review
  4. Africanized honeybee venom (Frontiers in immunology · 2024
    Article
  5. Review
  6. Launching a CDMO in Brazil aiming to develop biopharmaceuticals for clinical trials.The journal of venomous animals and toxins including tropical diseases · 2022
    Article
  7. A new therapeutic approach for bone metastasis in colorectal cancer: intratumoral melittin.The journal of venomous animals and toxins including tropical diseases · 2022
    Article
  8. Review
  9. Neuroactive venom compounds obtained fromThe journal of venomous animals and toxins including tropical diseases · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 3 countries.

Alexandre Naime BarbosaDepartment of Infectology, Dermatology, Imaging Diagnosis and Radiotherapy, Botucatu Medical School (FMB), São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, Brazil.
Rui Seabra FerreiraDepartment of Infectology, Dermatology, Imaging Diagnosis and Radiotherapy, Botucatu Medical School (FMB), São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, Brazil.
Francilene Capel Tavares de CarvalhoGraduate Program in Tropical Diseases, Botucatu Medical School (FMB), São Paulo State University (UNESP-Univ Estadual Paulista), Botucatu, Brazil.
Fabiana Schuelter-TrevisolClinical Research Center, Nossa Senhora da Conceição Hospital, Tubarão, Brazil.
Mônica Bannwart MendesDepartment of Infectology, Dermatology, Imaging Diagnosis and Radiotherapy, Botucatu Medical School (FMB), São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, Brazil.
Bruna Cavecci MendonçaGraduate Program in Tropical Diseases, Botucatu Medical School (FMB), São Paulo State University (UNESP-Univ Estadual Paulista), Botucatu, Brazil.
José Nixon BatistaClinical Research Center, Nossa Senhora da Conceição Hospital, Tubarão, Brazil.
Daisson José TrevisolClinical Research Center, Nossa Senhora da Conceição Hospital, Tubarão, Brazil.
Leslie BoyerVIPER Institute, University of Arizona College of Medicine, Tucson, AZ, United States.
Jean-Philippe ChippauxMERIT, IRD, Université Paris 5, Sorbonne Paris Cité, Paris, France.
Natália Bronzatto MedolagoClinical Research Unit (UPECLIN), Botucatu Medical School, São Paulo State University (UNESP-Univ Estadual Paulista), Botucatu, Brazil.
Claudia Vilalva CassaroGraduate Program in Tropical Diseases, Botucatu Medical School (FMB), São Paulo State University (UNESP-Univ Estadual Paulista), Botucatu, Brazil.
Márcia Tonin Rigotto CarneiroClinical Research Unit (UPECLIN), Botucatu Medical School, São Paulo State University (UNESP-Univ Estadual Paulista), Botucatu, Brazil.
Ana Paola Piloto de OliveiraClinical Research Unit (UPECLIN), Botucatu Medical School, São Paulo State University (UNESP-Univ Estadual Paulista), Botucatu, Brazil.
Daniel Carvalho PimentaGraduate Program in Tropical Diseases, Botucatu Medical School (FMB), São Paulo State University (UNESP-Univ Estadual Paulista), Botucatu, Brazil.
Luís Eduardo Ribeiro da CunhaAntivenom Production Laboratory, Vital Brazil Institute, Rio de Janeiro, Brazil.
Lucilene Delazari Dos SantosDepartment of Infectology, Dermatology, Imaging Diagnosis and Radiotherapy, Botucatu Medical School (FMB), São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, Brazil.
Benedito BarravieraDepartment of Infectology, Dermatology, Imaging Diagnosis and Radiotherapy, Botucatu Medical School (FMB), São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, Brazil.
Universidade Estadual Paulista (Unesp) · BRHospital Nossa Senhora da Conceição · BRInstituto Butantan · BRInstituto Vital Brazil (Brazil) · BRInstitut Pasteur · FRUniversidade do Sul de Santa Catarina · BRUniversity of Arizona · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We evaluated the safety, optimal dose, and preliminary effectiveness of a new-approach Africanized honeybee (

Indexed as

AdultAgedAnimalsAntiveninsBeesBee VenomsBrazilFemaleHumansInsect Bites and StingsMaleMiddle AgedSeverity of Illness IndexTreatment OutcomeYoung AdultAntiveninsBee VenomsantivenomApis mellifera (Africanized)clinical trialenzyme-linked immunosorbent assay (ELISA)safety assessment

Identifiers

PMID33841437
PMCPMC8025786
OpenAlexW3136883535

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.