Evidence map›Paper›PMID 33841293›Full record

ArticleFrontiers in neurology2021

Exploring How Low Oxygen Post Conditioning Improves Stroke-Induced Cognitive Impairment: A Consideration of Amyloid-Beta Loading and Other Mechanisms.

Zidan Zhao, Rebecca J Hood, Lin Kooi Ong, Giovanni Pietrogrande, Sonia Sanchez Bezanilla, Kirby E Warren, Marina Ilicic, Murielle G Kluge, Clifford TeBay, Ole P Ottersen and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

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  6. More than motor impairment: A spatiotemporal analysis of cognitive impairment and associated neuropathological changes following cortical photothrombotic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 4 countries.

Zidan ZhaoSchool of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW, Australia.
Rebecca J HoodSchool of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW, Australia.
Lin Kooi OngSchool of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW, Australia.
Giovanni PietrograndeSchool of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW, Australia.
Sonia Sanchez BezanillaSchool of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW, Australia.
Kirby E WarrenSchool of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW, Australia.
Marina IlicicSchool of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW, Australia.
Murielle G KlugeSchool of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW, Australia.
Clifford TeBaySchool of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW, Australia.
Ole P OttersenDivision of Anatomy, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Sarah J JohnsonSchool of Electrical Engineering and Computing, University of Newcastle, Newcastle, NSW, Australia.
Michael NilssonPriority Research Centre for Stroke and Brain Injury, University of Newcastle, Newcastle, NSW, Australia.
Frederick R WalkerSchool of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW, Australia.
Hunter Medical Research Institute · AUUniversity of Newcastle Australia · AUNational Health and Medical Research Council · AUKarolinska Institutet · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cognitive impairment is a common and disruptive outcome for stroke survivors, which is recognized to be notoriously difficult to treat. Previously, we have shown that low oxygen post-conditioning (LOPC) improves motor function and limits secondary neuronal loss in the thalamus after experimental stroke. There is also emerging evidence that LOPC may improve cognitive function post-stroke. In the current study we aimed to explore how exposure to LOPC may improve cognition post-stroke. Experimental stroke was induced using photothrombotic occlusion in adult, male C57BL/6 mice. At 72 h post-stroke animals were randomly assigned to either normal atmospheric air or to one of two low oxygen (11% O

Indexed as

amyloid beta - proteincognitive functionhypoxiaischemic strokeneural plasticityneuroprotection

Identifiers

PMID33841293
PMCPMC8024636
OpenAlexW3136570155

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.