ReviewFrontiers in human neuroscience2021
Global Signal Topography of the Human Brain: A Novel Framework of Functional Connectivity for Psychological and Pathological Investigations.
Review in Frontiers in human neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- CEST MRI reveals nicotine-induced alterations in glutamate-associated molecular connectivity in the mouse brain.Frontiers in neuroscience · 2026Article
- The functional overlap between respiration and global signal and its behavioral relevance.Communications biology · 2025Article
- The lifelong nonlinear development of spatial variability of brain signals.Communications biology · 2025Article
- Altered Global Signal Topography in Major Depressive Disorder With and Without Anxiety.Depression and anxiety · 2025Article
- Is depression a global brain disorder with topographic dynamic reorganization?Translational psychiatry · 2024Review
- Systematic cross-sectional age-associations in global fMRI signal topography.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Spatiotemporal dedifferentiation of the global brain signal topography along the adult lifespan.Human brain mapping · 2023Article
- Frequency-dependent effective connections between local signals and the global brain signal during resting-state.Cognitive neurodynamics · 2023Article
- Brain mechanisms of mental processing: from evoked and spontaneous brain activities to enactive brain activity.Psychoradiology · 2023Review
- Beyond noise to function: reframing the global brain activity and its dynamic topography.Communications biology · 2022Review
- The temporal dedifferentiation of global brain signal fluctuations during human brain ageing.Scientific reports · 2022Article
- Altered Global Signal Topography in Alcohol Use Disorders.Frontiers in aging neuroscience · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The global signal (GS), which was once regarded as a nuisance of functional magnetic resonance imaging, has been proven to convey valuable neural information. This raised the following question: what is a GS represented in local brain regions? In order to answer this question, the GS topography was developed to measure the correlation between global and local signals. It was observed that the GS topography has an intrinsic structure characterized by higher GS correlation in sensory cortices and lower GS correlation in higher-order cortices. The GS topography could be modulated by individual factors, attention-demanding tasks, and conscious states. Furthermore, abnormal GS topography has been uncovered in patients with schizophrenia, major depressive disorder, bipolar disorder, and epilepsy. These findings provide a novel insight into understanding how the GS and local brain signals coactivate to organize information in the human brain under various brain states. Future directions were further discussed, including the local-global confusion embedded in the GS correlation, the integration of spatial information conveyed by the GS, and temporal information recruited by the connection analysis. Overall, a unified psychopathological framework is needed for understanding the GS topography.
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Registered trials
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