Evidence map›Paper›PMID 33841098›Full record

ArticleFrontiers in molecular neuroscience2021

Deletion of BDNF in Pax2 Lineage-Derived Interneuron Precursors in the Hindbrain Hampers the Proportion of Excitation/Inhibition, Learning, and Behavior.

Philipp Eckert, Philine Marchetta, Marie K Manthey, Michael H Walter, Sasa Jovanovic, Daria Savitska, Wibke Singer, Michele H Jacob, Lukas Rüttiger, Thomas Schimmang and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Too Blind to See the Elephant? Why Neuroscientists Ought to Be Interested in Tinnitus.Journal of the Association for Research in Otolaryngology : JARO · 2021
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Philipp EckertDepartment of Otolaryngology, Head and Neck Surgery, Tübingen Hearing Research Centre, Molecular Physiology of Hearing, University of Tübingen, Tübingen, Germany.
Philine MarchettaDepartment of Otolaryngology, Head and Neck Surgery, Tübingen Hearing Research Centre, Molecular Physiology of Hearing, University of Tübingen, Tübingen, Germany.
Marie K MantheyDepartment of Otolaryngology, Head and Neck Surgery, Tübingen Hearing Research Centre, Molecular Physiology of Hearing, University of Tübingen, Tübingen, Germany.
Michael H WalterDepartment for Animal Physiology, Institute of Neurobiology, University of Tübingen, Tübingen, Germany.
Sasa JovanovicSchool of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.
Daria SavitskaDepartment of Otolaryngology, Head and Neck Surgery, Tübingen Hearing Research Centre, Molecular Physiology of Hearing, University of Tübingen, Tübingen, Germany.
Wibke SingerDepartment of Otolaryngology, Head and Neck Surgery, Tübingen Hearing Research Centre, Molecular Physiology of Hearing, University of Tübingen, Tübingen, Germany.
Michele H JacobDepartment of Neuroscience, Sackler School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA, United States.
Lukas RüttigerDepartment of Otolaryngology, Head and Neck Surgery, Tübingen Hearing Research Centre, Molecular Physiology of Hearing, University of Tübingen, Tübingen, Germany.
Thomas SchimmangInstituto de Biología y Genética Molecular, Consejo Superior de Investigaciones Científicas, Universidad de Valladolid, Valladolid, Spain.
Ivan MilenkovicSchool of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.
Peter K D PilzDepartment for Animal Physiology, Institute of Neurobiology, University of Tübingen, Tübingen, Germany.
Marlies KnipperDepartment of Otolaryngology, Head and Neck Surgery, Tübingen Hearing Research Centre, Molecular Physiology of Hearing, University of Tübingen, Tübingen, Germany.
University of Tübingen · DECarl von Ossietzky Universität Oldenburg · DETufts University · USUniversidad de Valladolid · ES

Funding

Molecular causes of cognitive and autistic disabilitiesR01MH106623 · NIMH · TUFTS UNIVERSITY BOSTON · PI JACOB, MICHELE H. · 2016 to 2020
$2.4M
NIMH NIH HHS R01 MH106623
6 · The paper itself

Abstract

Numerous studies indicate that deficits in the proper integration or migration of specific GABAergic precursor cells from the subpallium to the cortex can lead to severe cognitive dysfunctions and neurodevelopmental pathogenesis linked to intellectual disabilities. A different set of GABAergic precursors cells that express Pax2 migrate to hindbrain regions, targeting, for example auditory or somatosensory brainstem regions. We demonstrate that the absence of BDNF in Pax2-lineage descendants of

Indexed as

Arc/Arg3.1autism spectrum disorderBDNFGABAergic interneuronparvalbumin interneuronPax2

Identifiers

PMID33841098
PMCPMC8033028
OpenAlexW3140222426

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.