Evidence map›Paper›PMID 33841061›Full record

ArticleAdvanced functional materials2020

Designing Microgels for Cell Culture and Controlled Assembly of Tissue Microenvironments.

Alexander S Caldwell, Brian A Aguado, Kristi S Anseth

Abstract read
In one paragraph

Article in Advanced functional materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Edible Scaffolds for Cultivated Meat Production.Advances in biochemical engineering/biotechnology · 2026
    Review
  10. Article
  11. Article
  12. ATP-Powered Signaling Between Artificial and Living Cells.Angewandte Chemie (International ed. in English) · 2025
    Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Biofabrication and Characterization of Vascularizing PEG-Norbornene Microgels.Journal of biomedical materials research. Part A · 2025
    Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alexander S CaldwellDepartment of Chemical and Biological Engineering, University of Colorado - Boulder, USA, 80303.
Brian A AguadoDepartment of Chemical and Biological Engineering, University of Colorado - Boulder, USA, 80303.
Kristi S AnsethDepartment of Chemical and Biological Engineering, University of Colorado - Boulder, USA, 80303.

Funding

Osteogenic Hydrogel Niches to Promote hMSC Migration and DifferentiationR01DE016523 · NIDCR · UNIVERSITY OF COLORADO AT BOULDER · PI ANSETH, KRISTI S. · 2005 to 2023
$6.2M
Synthetic hydrogels to study formation and maintenance of intestinal cryptsR01DK120921 · NIDDK · UNIVERSITY OF COLORADO · PI KRISTI S. ANSETH, PETER J DEMPSEY · 2019 to 2026
$3.8M
Hydrogels to Study Synergistic Effects of Signaling Factors and Matrix Mechanics on Valve Disease ProgressionR01HL132353 · NHLBI · UNIVERSITY OF COLORADO · PI ANSETH, KRISTI S. · 2017 to 2020
$1.4M
Investigating sex differences in persistent valvular myofibroblast activation using hydrogel culture substratesR00HL148542 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AGUADO, BRIAN ALBERTO · 2021 to 2023
$1.1M
Investigating sex differences in persistent valvular myofibroblast activation using hydrogel culture substratesK99HL148542 · NHLBI · UNIVERSITY OF COLORADO · PI AGUADO, BRIAN ALBERTO · 2019 to 2020
$256k
Development of a nanotherapy for aortic valve stenosisF32HL137256 · NHLBI · UNIVERSITY OF COLORADO · PI AGUADO, BRIAN ALBERTO · 2017 to 2019
$134k
NHLBI NIH HHS F32 HL137256NHLBI NIH HHS K99 HL148542NHLBI NIH HHS R00 HL148542NHLBI NIH HHS R01 HL132353NIDCR NIH HHS R01 DE016523NIDDK NIH HHS R01 DK120921
6 · The paper itself

Abstract

Micron-sized hydrogels, termed microgels, are emerging as multifunctional platforms that can recapitulate tissue heterogeneity in engineered cell microenvironments. The microgels can function as either individual cell culture units or can be assembled into larger scaffolds. In this manner, individual microgels can be customized for single or multi-cell co-culture applications, or heterogeneous populations can be used as building blocks to create microporous assembled scaffolds that more closely mimic tissue heterogeneities. The inherent versatility of these materials allows user-defined control of the microenvironments, from the order of singly encapsulated cells to entire three-dimensional cell scaffolds. These hydrogel scaffolds are promising for moving towards personalized medicine approaches and recapitulating the multifaceted microenvironments that exist

Indexed as

Assembled networksCell cultureHydrogelsMicrogelsTissue regeneration

Identifiers

PMID33841061
PMCPMC8026140

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.