Evidence map›Paper›PMID 33841059›Full record

ArticleJournal of applied crystallography2021

High-pressure small-angle X-ray scattering cell for biological solutions and soft materials.

Durgesh K Rai, Richard E Gillilan, Qingqiu Huang, Robert Miller, Edmund Ting, Alexander Lazarev, Mark W Tate, Sol M Gruner

Open access · greenAbstract read
In one paragraph

Article in Journal of applied crystallography, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Homeostatic regulation of intrinsic lipid curvature in eukaryotic cells.bioRxiv : the preprint server for biology · 2025
    Article
  5. Review
  6. Solution conformational differences between conventional and CENP-A nucleosomes are accentuated by reversible deformation under high pressure.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Pressure pushes tRNAProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  13. Small-angle X-ray scattering studies of enzymes.Current opinion in chemical biology · 2023
    Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Durgesh K RaiCornell High Energy Synchrotron Source (CHESS), Cornell University, Ithaca, NY 14853, USA.ORCID https://orcid.org/0000-0001-7257-7210
Richard E GillilanCornell High Energy Synchrotron Source (CHESS), Cornell University, Ithaca, NY 14853, USA.ORCID https://orcid.org/0000-0002-7636-3188
Qingqiu HuangCornell High Energy Synchrotron Source (CHESS), Cornell University, Ithaca, NY 14853, USA.
Robert MillerCornell High Energy Synchrotron Source (CHESS), Cornell University, Ithaca, NY 14853, USA.ORCID https://orcid.org/0000-0002-0211-7515
Edmund TingPressure BioSciences Inc., South Easton, MA 02375, USA.
Alexander LazarevPressure BioSciences Inc., South Easton, MA 02375, USA.
Mark W TateLaboratory of Atomic and Solid State Physics, Cornell University, Ithaca, NY 14853, USA.
Sol M GrunerCornell High Energy Synchrotron Source (CHESS), Cornell University, Ithaca, NY 14853, USA.ORCID https://orcid.org/0000-0002-1171-4426
Cornell University · USPressure BioSciences (United States) · US

Funding

Training and OutreachP30GM124166 · NIGMS · CORNELL UNIVERSITY · PI RICHARD A. CERIONE · 2019 to 2026
$28.3M
NIGMS NIH HHS P30 GM124166
6 · The paper itself

Abstract

Pressure is a fundamental thermodynamic parameter controlling the behavior of biological macromolecules. Pressure affects protein denaturation, kinetic parameters of enzymes, ligand binding, membrane permeability, ion trans-duction, expression of genetic information, viral infectivity, protein association and aggregation, and chemical processes. In many cases pressure alters the molecular shape. Small-angle X-ray scattering (SAXS) is a primary method to determine the shape and size of macromolecules. However, relatively few SAXS cells described in the literature are suitable for use at high pressures and with biological materials. Described here is a novel high-pressure SAXS sample cell that is suitable for general facility use by prioritization of ease of sample loading, temperature control, mechanical stability and X-ray background minimization. Cell operation at 14 keV is described, providing a

Indexed as

high-pressure biologysmall-angle X-ray scatteringsynchrotron instrumentation

Identifiers

PMID33841059
PMCPMC7941318
OpenAlexW3111373062

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.