ArticleThe Journal of veterinary medical science2021
Copper-associated hepatitis in a young Dalmatian dog in Japan.
Article in The Journal of veterinary medical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Copper analysis of laparoscopic liver biopsy tissue samples from cats.The Journal of veterinary medical science · 2026Article
- Pedigree study of the heredity of copper-associated hepatitis in Dalmatians in Japan.The Canadian veterinary journal = La revue veterinaire canadienne · 2022Article
- Risk model of hepatocellular carcinoma based on cuproptosis-related genes.Frontiers in genetics · 2022Article
- Prognostic and immune correlation evaluation of a novel cuproptosis-related genes signature in hepatocellular carcinoma.Frontiers in pharmacology · 2022Article
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A male 25-month-old Dalmatian dog attended our veterinary hospital because of anorexia and high circulating liver enzyme activities. Abdominal computed tomography showed a slightly small liver with rounded edges, and laparoscopic examination showed that the liver was yellowish. Histopathological examination revealed multifocal necrosis of hepatocytes and severe chronic hepatitis. Rhodanine staining showed severe copper accumulation in hepatocytes and a quantitative analysis of the copper content of the liver showed substantial accumulation (10.3 mg/g dry mass), suggesting a diagnosis of copper-associated hepatitis. Previously reported canine mutation in the COMMD1, the gene responsible for the copper-associated hepatitis in the Bedlington terrier, was not identified. To our knowledge, this is the first report of copper-associated hepatitis in a Dalmatian in Japan.
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Registered trials
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