Evidence map›Paper›PMID 33840391›Full record

SynthesisBMC endocrine disorders2021

Lithium carbonate as add-on therapy to radioiodine in the treatment on hyperthyroidism: a systematic review and meta-analysis.

Mohamed Abd-ElGawad, Mohamed Abdelmonem, Ahmed Eissa Ahmed, Omar Magdy Mohammed, Mohamed Sayed Zaazouee, Ahmed Assar, Mohamed Gadelkarim, Ahmed M Afifi

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC endocrine disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Mohamed Abd-ElGawadFaculty of Medicine, Fayoum University, 5 Al-Touba Street, from Al-Fanya Street, Al-Hadka road, Fayoum, Fayoum, Egypt. mohammed.mahmod87@gmail.com.ORCID https://orcid.org/0000-0003-4120-9161
Mohamed AbdelmonemFaculty of Medicine, Fayoum University, 5 Al-Touba Street, from Al-Fanya Street, Al-Hadka road, Fayoum, Fayoum, Egypt.
Ahmed Eissa AhmedFaculty of Medicine, Fayoum University, 5 Al-Touba Street, from Al-Fanya Street, Al-Hadka road, Fayoum, Fayoum, Egypt.
Omar Magdy MohammedFaculty of Medicine, Fayoum University, 5 Al-Touba Street, from Al-Fanya Street, Al-Hadka road, Fayoum, Fayoum, Egypt.
Mohamed Sayed ZaazoueeFaculty of Medicine, Al-Azhar University, Assiut, Egypt.
Ahmed AssarFaculty of Medicine, Menofia University, Shebin El-Kom, Menofia, Egypt.
Mohamed GadelkarimFaculty of Medicine, Alexandria University, Alexandria, Egypt.
Ahmed M AfifiDepartment of Internal Medicine and Division of Digestive Diseases, College of Medicine, University of Kentucky, Lexington, USA.
Fayoum University · EGAl-Azhar University · EGAlexandria University · EGMenoufia University · EGUniversity of Kentucky · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe main purpose is to investigate the effect of LiCO3 as an add-on therapy with radioactive iodine in increasing the cure and decreasing the T4 level compared to radioactive iodine alone. The primary outcome is the cure rate as defined by the number of hyperthyroid patients who became euthyroid or hypothyroid. The secondary outcome is the T4 level.

methodsFour databases were searched (PubMed, Scopus, Web of Science, and Cochrane central library). The inclusion criteria were randomized and non-randomized clinical trials of hyperthyroidism patients receiving LiCO3 with radioiodine compared with hyperthyroidism patients receiving radioactive iodine alone. Included studies were appraised with the risk of bias version 2 tool, according to the Cochrane Handbook for Systematic Reviews of Interventions 5.1.0.

resultsNine studies were eligible for inclusion in the study, six randomized control trials and three non-randomized control trials. There were 477 patients in the intervention group and 451 patients in the control group. The cure rate was not significantly different between the two groups, while it was significantly increased with 5000 to 6500 mg optimized cumulative dose of LiCO3 compared with the control group, P = 0.0001. The T4 level showed no significant difference between the two groups, P = 0.13.

conclusionsLiCO3 adjunct to radioactive iodine did not show significant differences compared with radioactive iodine alone in terms of cure rate or decreasing T4 level. However, the dose of 5000 to 6000 mg of LiCO3 may increase the cure rate.

Indexed as

Chemotherapy, AdjuvantHumansHyperthyroidismIodine RadioisotopesLithium CarbonateRandomized Controlled Trials as TopicThyroxineTreatment OutcomeIodine RadioisotopesLithium CarbonateThyroxineCure rateHyperthyroidismLithium carbonateRadioactive iodine

Identifiers

PMID33840391
PMCPMC8040242
OpenAlexW3153648627

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.