Evidence map›Paper›PMID 33840251›Full record

ArticleJournal of dental research2021

Delivery of Alkaline Phosphatase Promotes Periodontal Regeneration in Mice.

A Nagasaki, K Nagasaki, B D Kear, W D Tadesse, V Thumbigere-Math, J L Millán, B L Foster, M J Somerman

Open access · greenAbstract read
In one paragraph

Article in Journal of dental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 16 citations in OpenAlex.

  1. The Therapeutic Potential of Purmorphamine Across Disease Models.Journal of cellular and molecular medicine · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Impaired Tertiary Dentin Secretion after Shallow Injury inInternational journal of molecular sciences · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

A NagasakiLaboratory of Oral Connective Tissue Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-7655-9658
K NagasakiLaboratory of Oral Connective Tissue Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
B D KearLaboratory of Oral Connective Tissue Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
W D TadesseLaboratory of Oral Connective Tissue Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
V Thumbigere-MathDivision of Periodontology, School of Dentistry, University of Maryland, Baltimore, MD, USA.
J L MillánSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
B L FosterBiosciences Division, College of Dentistry, The Ohio State University, Columbus, OH, USA.ORCID 0000-0003-3444-0576
M J SomermanLaboratory of Oral Connective Tissue Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
National Institutes of Health · USSanford Burnham Prebys Medical Discovery Institute · USThe Ohio State University · USUniversity of Maryland, Baltimore · US

Funding

MOLECULAR PATHOGENESIS/TREATMENT OF HYPOPHOSPHATASIAR01DE012889 · NIDCR · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI MILLAN, JOSE LUIS · 1999 to 2020
$9.2M
Functions of extracellular matrix proteins in dental and skeletal mineralizationR01DE027639 · NIDCR · OHIO STATE UNIVERSITY · PI Brian Lee Foster · 2019 to 2026
$2.3M
The Role of Interferon Regulatory Factor 8 (IRF8) in Periodontal DiseaseR00DE028439 · NIDCR · UNIVERSITY OF MARYLAND BALTIMORE · PI THUMBIGERE-MATH, VIVEK · 2018 to 2020
$747k
Role of tissue-nonspecific alkaline phosphatase in dentoalveolar development and diseaseR03DE028411 · NIDCR · OHIO STATE UNIVERSITY · PI FOSTER, BRIAN LEE · 2019 to 2020
$312k
Conditional Deletion of Irf8 in Monocyte Macrophage Lineage Provides Novel Insight into Irf8s Important Function in Osteoclast Regulation and Bone MetabolismR03DE029258 · NIDCR · UNIVERSITY OF MARYLAND BALTIMORE · PI THUMBIGERE-MATH, VIVEK · 2020 to 2021
$309k
NIDCR NIH HHS K99 DE028439NIDCR NIH HHS R00 DE028439NIDCR NIH HHS R01 DE012889NIDCR NIH HHS R01 DE027639NIDCR NIH HHS R03 DE028411NIDCR NIH HHS R03 DE029258
6 · The paper itself

Abstract

Factors regulating the ratio of pyrophosphate (PP

Indexed as

Alkaline PhosphataseDental CementumAnimalsCalcification, PhysiologicCattleIntegrin-Binding SialoproteinMiceMice, KnockoutX-Ray MicrotomographyAlkaline PhosphataseIntegrin-Binding Sialoproteinbiomineralizationbone regenerationcementogenesisextracellular matrixperiodontiumphosphates

Identifiers

PMID33840251
PMCPMC8295954
OpenAlexW3154757065

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.