Evidence map›Paper›PMID 33840006›Full record

ArticleThe protein journal2021

Milk Peptides as Novel Multi-Targeted Therapeutic Candidates for SARS-CoV2.

H Pradeep, Umme Najma, H S Aparna

Abstract read
In one paragraph

Article in The protein journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Milk Antiviral Proteins and Derived Peptides against Zoonoses.International journal of molecular sciences · 2024
    Review
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

H PradeepDepartment of Studies in Biotechnology, University of Mysore, Manasagangotri, Mysuru, Karnataka, 570 006, India.
Umme NajmaDepartment of Studies in Biotechnology, University of Mysore, Manasagangotri, Mysuru, Karnataka, 570 006, India.
H S AparnaDepartment of Studies in Biotechnology, University of Mysore, Manasagangotri, Mysuru, Karnataka, 570 006, India. hsa.uom@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The COVID-19, an acute respiratory syndrome caused by SARS-CoV2 is a major catastrophic event of the twenty first century. Relentless efforts for the development of effective pharmaco-therapeutics are in progress but the respite is the development of effective vaccines. However, monotherapy might not always exhibit complete efficacy and may culminate in the rapid evolution of drug-resistant viral strains. Hence, simultaneous modulation of multiple druggable targets not only enhances therapeutic efficacy but also quell the prospects of mutant viruses. Currently, milk peptides have bloomed beyond just being a quintessential part of nutrition to prominent therapeutic implications in human health and diseases. Hence, we have focused on colostrum/milk peptides as they have already been acknowledged for their high potency, target specificity with significantly low or no side effects and bio-toleration. The results presented provide a conceptual strategy for the rational designing of prospective multitargeted peptide inhibitors for SARS-CoV2.

Indexed as

COVID-19 Drug TreatmentMolecular Docking SimulationAnimalsAntiviral AgentsCattleHumansPeptidesSARS-CoV-2Whey ProteinsAntiviral AgentsPeptidesWhey ProteinsMilk peptidesMolecular dockingMolecular dynamicsSARS-CoV2Targets

Identifiers

PMID33840006
PMCPMC8036162

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.