ReviewMolecular biology reports2021
Mobilized colistin resistance (mcr) genes from 1 to 10: a comprehensive review.
Review in Molecular biology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 162 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
162 citing papers in PubMed, 1 synthesis or guideline pooled it, 279 citations in OpenAlex.
- Global prevalence of mutation in theFrontiers in microbiology · 2024Pooled it
- Bloodstream infections in adult patients with malignancy, epidemiology, microbiology, and risk factors associated with mortality and multi-drug resistance.BMC infectious diseases · 2021Trial
- Genomic insights into multidrug-resistant bacteria: Emergence ofVirulence · 2026Article
- Prevalence and molecular characteristics of colistin-resistant Escherichia coli in livestock and fresh meat detected by a selective enrichment method.Veterinary research communications · 2026Article
- Antimicrobial Activity of a Polymyxin A-like Compound and Characterisation of the Cognate Biosynthetic Gene Cluster Within the Genome of the ProducingAntibiotics (Basel, Switzerland) · 2026Article
- Molecular Characterization of Virulence Genes and Quinolone Resistance Determinants inAntibiotics (Basel, Switzerland) · 2026Article
- Metacycloprodigiosin produced by a high-yieldOrganic & biomolecular chemistry · 2026Article
- Novel polymyxin resistance gene family mcr-12 from environmental Pigmentiphaga litoralis.Nature communications · 2026Article
- ReGAIN: a bioinformatics platform for assessing probabilistic co-occurrence between resistance genes in bacterial pathogens.Bioinformatics (Oxford, England) · 2026Article
- Bacteriocins in Veterinary Medicine: From Antibiotic Limitations to Targeted Solutions.International journal of molecular sciences · 2026Review
- Prevalence and Genomic Characterization of mcr-1-Positive Escherichia coli from Livestock in Hunan Province, China (2016-2021).Current microbiology · 2026Article
- Antimicrobial Resistance and Genomic Characterization of FourAntibiotics (Basel, Switzerland) · 2026Article
- First report and genomic characterization of an mcr-10.1-carrying Enterobacter kobei strain isolated from a domestic kitchen sink in China.BMC microbiology · 2026Article
- Persistence and Environmental Dissemination of a NovelMicroorganisms · 2026Article
- Genomic and GWAS-Based Insights into Antimicrobial Resistance inAntibiotics (Basel, Switzerland) · 2026Article
- Synthesis and synergistic antibacterial activity of rafoxanide derivative as a novel drug for potentiating colistin activity.Microbiology spectrum · 2026Article
- Perspectives on Colistin-An Old Antibiotic with Renewed Relevance in Modern Medicine.International journal of molecular sciences · 2026Review
- Global genomic characteristics of mobile colistin resistance mcr genes in Enterobacterales from companion animals.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Genomic analysis of a multidrug-resistant monophasic Salmonella Typhimurium from Chinese beef harboring a novel mcr-1-bearing IncHI2-IncHI2A plasmid.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Molecular basis of carbapenem and colistin resistance andMicrobiology spectrum · 2026Article
102 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
At the present time, the polymyxin antibiotic colistin is considered a last-line treatment option for severe human infections caused by multi-drug and carbapenem-resistant Gram-negative bacteria. Lately, the vast spread of colistin resistance among bacteria has got great attention worldwide due to its significant role as the last refuge in treating diseases caused by the resistant infectious agents. Therefore, the discovery of plasmid-mediated mobile colistin resistance (mcr) genes raised global public health concerns as they can spread by horizontal transfer and have chances of global dissemination. To date, ten slightly different variants of the mcr-1 gene (mcr-1 to mcr-10) have been identified in different bacteria isolated from animals, foods, farms, humans, and the environment. Therefore, the issue of mcr spread is growing and worsening day after day. In this backdrop, the current article presents an overview of mcr variants, their spread, and the resistance mechanisms they confer. Hence, this paper will advance our knowledge about colistin resistance while supporting the efforts toward better stewardship and proper usage of antimicrobials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.