ArticleEuropean journal of nuclear medicine and molecular imaging2021
Neuropathological correlation supports automated image-based differential diagnosis in parkinsonism.
Article in European journal of nuclear medicine and molecular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A replication study, systematic review and meta-analysis of automated image-based diagnosis in parkinsonism.Scientific reports · 2022Pooled it
- A review of FDG-PET biomarker analysis methods in Parkinson's disease.Journal of Parkinson's disease · 2026Review
- The role of neuro-imaging in multiple system atrophy.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- A data-driven SSM/PCA analysis approach for differential diagnosis of parkinsonism usingNeuroImage. Clinical · 2026Article
- Review
- Positron Emission Tomography Imaging in Clinical Trials for Parkinson's Disease: Applications of Metabolic Brain Network Approach.Movement disorders : official journal of the Movement Disorder Society · 2025Review
- Relationships Between Glymphatic System Activity and Tau Burden, Dopaminergic Impairment, Abnormal Glucose Metabolism in Progressive Supranuclear Palsy.CNS neuroscience & therapeutics · 2025Article
- Synaptic density patterns in early Alzheimer's disease assessed by independent component analysis.Brain communications · 2024Article
- Functional Brain Networks to Evaluate Treatment Responses in Parkinson's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Article
- Functional brain networks in the evaluation of patients with neurodegenerative disorders.Nature reviews. Neurology · 2023Review
- Stereotyped Relationship Between Motor and Cognitive Metabolic Networks in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2022Article
- Imaging Dopaminergic Neurotransmission in Neurodegenerative Disorders.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
purposeUp to 25% of patients diagnosed as idiopathic Parkinson's disease (IPD) have an atypical parkinsonian syndrome (APS). We had previously validated an automated image-based algorithm to discriminate between IPD, multiple system atrophy (MSA), and progressive supranuclear palsy (PSP). While the algorithm was accurate with respect to the final clinical diagnosis after long-term expert follow-up, its relationship to the initial referral diagnosis and to the neuropathological gold standard is not known.
methodsPatients with an uncertain diagnosis of parkinsonism were referred for
resultsAt the time of referral to PET, the clinical impression was only 66.7% accurate. The algorithm correctly identified 80% of the cases as IPD or APS (p = 0.02) and 87.5% of the APS cases as MSA or PSP (p = 0.03). The final clinical diagnosis was 93.3% accurate (p < 0.001), but needed several years of expert follow-up.
conclusionThe image-based classifications agreed well with autopsy and can help to improve diagnostic accuracy during the period of clinical uncertainty.
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