Evidence map›Paper›PMID 33839864›Full record

ArticleActa neurochirurgica. Supplement2021

Single Center Experience in Cerebrospinal Fluid Dynamics Testing.

Zofia H Czosnyka, Marek Czosnyka, Piotr Smielewski, Afroditi D Lalou, Eva Nabbanja, Matthew Garnett, Slawomir Barszcz, Eric A Schmidt, Shahan Momjian, Magda Kasprowicz and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Acta neurochirurgica. Supplement, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 7 countries.

Zofia H CzosnykaDivision of Neurosurgery, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
Marek CzosnykaDivision of Neurosurgery, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK. Mc141@medschl.cam.ac.uk.
Piotr SmielewskiDivision of Neurosurgery, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
Afroditi D LalouDivision of Neurosurgery, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
Eva NabbanjaDivision of Neurosurgery, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
Matthew GarnettDivision of Neurosurgery, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
Slawomir BarszczNeurosurgery, Medical Academy Pediatric Hospital, ul Zwirki I Wigury, Warsaw, Poland.
Eric A SchmidtNeurosurgery, Pourpan Hospital, University of Toulouse, Toulouse, France.
Shahan MomjianDepartment of Neurosurgery, Geneva University Hospital, Geneva, Switzerland.
Magda KasprowiczDepartment of Biomedical Engineering, Wroclaw University of Science and Technology, Wroclaw, Poland.
Gianpaolo PetrellaDepartment of Neurosurgery, Hospital Santa Maria Goretti, Latina, Italy.
Brian OwlerPaediatrics and Child Health, The Children's Hospital at Westmead Clinical School, Sydney, NSW, Australia.
Nicole C KeongNational Neuroscience Institute, Duke-NUS Medical School, Singapore, Singapore.
Peter J HutchinsonDivision of Neurosurgery, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
John D PickardDivision of Neurosurgery, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
Addenbrooke's Hospital · GBUniversity of Cambridge · GBChildren's Hospital at Westmead · AUDuke-NUS Medical School · SGOspedale Santa Maria Goretti · ITUniversité de Toulouse · FRUniversity Hospital of Geneva · CHWrocław University of Science and Technology · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Normal pressure hydrocephalus is more complex than a simple disturbance of the cerebrospinal fluid (CSF) circulation. Nevertheless, an assessment of CSF dynamics is key to making decisions about shunt insertion, shunt malfunction, and for further management if a patient fails to improve. We summarize our 25 years of single center experience in CSF dynamics assessment using pressure measurement and analysis. 4473 computerized infusion tests have been performed. We have shown that CSF infusion studies are safe, with incidence of infection at less than 1%. Raised resistance to CSF outflow positively correlates (p < 0.014) with improvement after shunting and is associated with disturbance of cerebral blood flow and its autoregulation (p < 0.02). CSF infusion studies are valuable in assessing possible shunt malfunction in vivo and for avoiding unnecessary revisions. Infusion tests are safe and provide useful information for clinical decision-making for the management of patients suffering from hydrocephalus.

Indexed as

Hydrocephalus, Normal PressureCerebrospinal FluidCerebrospinal Fluid ShuntsCerebrovascular CirculationHomeostasisHumansIntracranial PressureCerebrospinal fluidHydrocephalusInfusion testShunt

Identifiers

PMID33839864
OpenAlexW3155672632

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.