Evidence map›Paper›PMID 33839835›Full record

Trial reportActa neurochirurgica. Supplement2021

An Update on the COGiTATE Phase II Study: Feasibility and Safety of Targeting an Optimal Cerebral Perfusion Pressure as a Patient-Tailored Therapy in Severe Traumatic Brain Injury.

Jeanette Tas, Erta Beqiri, C R van Kaam, Ari Ercole, Gert Bellen, D Bruyninckx, Manuel Cabeleira, Marek Czosnyka, Bart Depreitere, Joseph Donnelly and 10 more

Abstract readClinical Trial, Phase II
PubMed Publisher
In one paragraph

Trial report in Acta neurochirurgica. Supplement, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
21.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 9 institutions in 6 countries.

Jeanette TasDepartment of Intensive Care Medicine, University of Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands. Jeanette.tas@mumc.nl.
Erta BeqiriBrain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
C R van KaamDepartment of Intensive Care Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands.
Ari ErcoleUniversity Division of Anaesthesia, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
Gert BellenDepartment of Neurosciences, Catholic University Leuven, University Hospital Leuven, Leuven, Belgium.
D BruyninckxDepartment of Neurosciences, Catholic University Leuven, University Hospital Leuven, Leuven, Belgium.
Manuel CabeleiraBrain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Marek CzosnykaBrain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Bart DepreitereDepartment of Neurosciences, Catholic University Leuven, University Hospital Leuven, Leuven, Belgium.
Joseph DonnellyBrain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Marta FedrigaBrain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Peter J HutchinsonDepartment of Clinical Neurosciences, Cambridge University, Cambridge, UK.
D MenonUniversity Division of Anaesthesia, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
Geert MeyfroidtDepartment of Cellular and Molecular Medicine, Catholic University Leuven, University Hospital, Leuven, Belgium.
Annalisa LibertiDepartment of Intensive Care Medicine, University of Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands.
J G OuttrimUniversity Division of Anaesthesia, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
C RobbaDepartment of Anaesthesia and Intensive Care, Policlinico San Martino, IRCCS for Oncology and Neuroscience, Genoa, Italy.
C W E HoedemaekersDepartment of Intensive Care Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands.
Peter SmielewskiBrain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Marcel J AriesDepartment of Intensive Care Medicine, University of Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands.
University of Cambridge · GBMaastricht University Medical Centre · NLCatholic University of America · USKU Leuven · BEAddenbrooke's Hospital · GBBridge University · SSOspedale Policlinico San Martino · ITRadboud University Medical Center · NLRadboud University Nijmegen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMonitoring of cerebral autoregulation (CA) in patients with a traumatic brain injury (TBI) can provide an individual 'optimal' cerebral perfusion pressure (CPP) target (CPPopt) at which CA is best preserved. This potentially offers an individualized precision medicine approach. Retrospective data suggest that deviation of CPP from CPPopt is associated with poor outcomes. We are prospectively assessing the feasibility and safety of this approach in the COGiTATE [CPPopt Guided Therapy: Assessment of Target Effectiveness] study. Its primary objective is to demonstrate the feasibility of individualizing CPP at CPPopt in TBI patients. The secondary objectives are to investigate the safety and physiological effects of this strategy.

methodsThe COGiTATE study has included patients in four European hospitals in Cambridge, Leuven, Nijmegen, and Maastricht (coordinating centre). Patients with severe TBI requiring intracranial pressure (ICP)-directed therapy are allocated into one of two groups. In the intervention group, CPPopt is calculated using a published (modified) algorithm. In the control group, the CPP target recommended in the Brain Trauma Foundation guidelines (CPP 60-70 mmHg) is used.

resultsPatient recruitment started in February 2018 and will continue until 60 patients have been studied. Fifty-one patients (85% of the intended total) have been recruited in October 2019. The first results are expected early 2021.

conclusionThis prospective evaluation of the feasibility, safety and physiological implications of autoregulation-guided CPP management is providing evidence that will be useful in the design of a future phase III study in severe TBI patients.

Indexed as

Brain Injuries, TraumaticIntracranial PressureCerebrovascular CirculationFeasibility StudiesHumansRetrospective StudiesCerebral autoregulationCOGiTATECPPoptOptimal cerebral perfusion pressurePRx

Identifiers

PMID33839835
OpenAlexW3155607617

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.