Evidence map›Paper›PMID 33839815›Full record

ArticleActa neurochirurgica. Supplement2021

Analysis of Cardio-Cerebral Crosstalk Events in an Adult Cohort from the CENTER-TBI Study.

Giovanna Maria Dimitri, Erta Beqiri, Marek Czosnyka, Ari Ercole, Peter Smielewski, Pietro Lio, CENTER-TBI High Resolution Substudy Participants and Investigators

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In one paragraph

Article in Acta neurochirurgica. Supplement, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Giovanna Maria DimitriComputer Laboratory, University of Cambridge, Cambridge, UK. gmd43@cl.cam.ac.uk.
Erta BeqiriBrain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK.
Marek CzosnykaBrain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK.
Ari ErcoleBrain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK.
Peter Smielewski *Brain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK.
Pietro Lio *Computer Laboratory, University of Cambridge, Cambridge, UK.
CENTER-TBI High Resolution Substudy Participants and Investigators
University of Cambridge · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveIn a previous study, we observed the presence of simultaneous increases in intracranial pressure (ICP) and the heart rate (HR), which we denominated cardio-cerebral crosstalk (CC), and we related the number of such events to patient outcomes in a paediatric cohort. In this chapter, we present an extension of this work to an adult cohort from the Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI) study.

methodsWe implemented a sliding window algorithm to detect CC events. We considered subwindows of 10-min observations. If simultaneous increases of at least 20% in ICP and HR occurred with respect to the minimum ICP and HR values in the time windows, a CC event was detected. Correlation between the number of CC events and mortality was then obtained.

resultsThe cohort consisted of 226 adults (aged 16-85 years). The number of CC events that were detected varied (mean 50, standard deviation 58). A point biserial correlation coefficient of -0.13 between mortality and CC was found. Although the correlation was weaker than that seen in the paediatric cohort (-0.30), the negative direction was replicated.

conclusionIn this work, we first extracted CC events from ICP and HR observations of adult patients with traumatic brain injury and related the number of CC events to patient outcomes. Consistency with the previous results in the paediatric cohort was observed. The more crosstalk events occurred, the better the patient outcome was.

Indexed as

Brain Injuries, TraumaticAdolescentAdultAgedAged, 80 and overAlgorithmsChildCohort StudiesHeart RateHumansIntracranial PressureMiddle AgedYoung AdultCENTER-TBICrosstalkHeart rateIntracranial pressurePeak detectionRecurrence plots

Identifiers

PMID33839815
OpenAlexW3155247819

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.