Evidence map›Paper›PMID 33839699›Full record

ArticleAging2021

Inhibition of long non-coding RNA HOXA11-AS against neuroinflammation in Parkinson's disease model via targeting miR-124-3p mediated FSTL1/NF-κB axis.

Hua Cao, Xinsheng Han, Yonglin Jia, Baohua Zhang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hua CaoDepartment of Neurology, Kaifeng Central Hospital, Kaifeng 475000, Henan, China.
Xinsheng HanDepartment of Neurology, Kaifeng Central Hospital, Kaifeng 475000, Henan, China.
Yonglin JiaDepartment of Neurology, Kaifeng Central Hospital, Kaifeng 475000, Henan, China.
Baohua ZhangDepartment of Neurology, Kaifeng Central Hospital, Kaifeng 475000, Henan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStudies have revealed that lncRNA HOXA11-AS contributes to regulating inflammation, while the role of HOXA11-AS in Parkinson's disease (PD) remains unclear.

methodsBoth

resultsHOXA11-AS promoted MPTP-mediated SH-SY5Y neuronal injury and LPS-induced microglia activation, while miR-124-3p had the opposite effects. Additionally, miR-124-3p was the target of HOXA11-AS and FSTL1. HOXA11-AS overexpression enhanced the expression of inflammatory factors and FSTL1, NF-κB and NLRP3 inflammasome, while inhibiting NF-κB weakened HOXA11-AS-mediated neuronal damage and microglia activation. Moreover, HOXA11-AS1 downregulation ameliorated MPTP-induced neurological damages and neuroinflammation in mice.

conclusionInhibition of HOXA11-AS protects mice against PD through repressing neuroinflammation and neuronal apoptosis through miR-124-3p-FSTL1-NF-κB axis.

Indexed as

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsApoptosisDisease Models, AnimalDopaminergic NeuronsFollistatin-Related ProteinsHumansInflammasomesMaleMiceMicroRNAsNF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinParkinsonian DisordersRNA, Long NoncodingSignal Transduction1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineFollistatin-Related ProteinsFSTL1 protein, humanFstl1 protein, mouseInflammasomesMicroRNAsMIRN124 microRNA, humanMirn124 microRNA, mouseNF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanNlrp3 protein, mouseRNA, Long NoncodingFSTL1HOXA11-ASmiR-124-3pNF-κBParkinson's disease

Identifiers

PMID33839699
PMCPMC8109130
OpenAlexW3139857577

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.