Evidence map›Paper›PMID 33839323›Full record

ReviewMolecular therapy : the journal of the American Society of Gene Therapy2021

The evolving landscape of N

Yunru Gu, Xi Wu, Jingxin Zhang, Yuan Fang, Yutian Pan, Yongqian Shu, Pei Ma

Open access · bronzeAbstract readReview
In one paragraph

Review in Molecular therapy : the journal of the American Society of Gene Therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed
8.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 99 citations in OpenAlex.

  1. Article
  2. Review
  3. Polymeric Nanocarriers with pH-Dependent Release for Tumor-Specific Delivery.Recent advances in drug delivery and formulation · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. The mMolecular biomedicine · 2025
    Review
  9. RNA mDiscover oncology · 2025
    Article
  10. Article
  11. Epigenetic orchestration of RNA mInternational journal of biological sciences · 2025
    Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Progression of mCell death discovery · 2024
    Review
  19. Review
  20. Role of mMedical oncology (Northwood, London, England) · 2024
    Review

19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Yunru GuDepartment of Oncology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, People's Republic of China.
Xi WuDepartment of Oncology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, People's Republic of China.
Jingxin ZhangDepartment of General Surgery, The Affiliated People's Hospital of Jiangsu University, Zhenjiang Clinic School of Nanjing Medical University, Zhenjiang 212002, People's Republic of China.
Yuan FangDepartment of Oncology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, People's Republic of China.
Yutian PanDepartment of Oncology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, People's Republic of China.
Yongqian ShuDepartment of Oncology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, People's Republic of China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing 211166, People's Republic of China. Electronic address: yongqian_shu@163.com.
Pei MaDepartment of Oncology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, People's Republic of China. Electronic address: mapei@njmu.edu.cn.
Jiangsu Province Hospital · CNNanjing Medical University · CNAffiliated Hospital of Jiangsu University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The tumor microenvironment (TME), controlled by intrinsic mechanisms of carcinogenesis and epigenetic modifications, has, in recent years, become a heavily researched topic. The TME can be described in terms of hypoxia, metabolic dysregulation, immune escape, and chronic inflammation. RNA methylation, an epigenetic modification, has recently been found to have a pivotal role in shaping the TME. The N

Indexed as

AdenosineBiomarkers, TumorDisease ProgressionEpigenesis, GeneticGene Expression Regulation, NeoplasticHumansNeoplasmsTumor MicroenvironmentAdenosineBiomarkers, TumorN-methyladenosinechronic inflammationhypoxiaimmune escapem(6)Ametabolic dysregulationRNA methylationtumor microenvironment

Identifiers

PMID33839323
PMCPMC8116604
OpenAlexW3152360957

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.