Evidence map›Paper›PMID 33839113›Full record

ArticleDevelopmental biology2021

Altered sacral neural crest development in Pax3 spina bifida mutants underlies deficits of bladder innervation and function.

Karen K Deal, Anoop S Chandrashekar, M Makenzie Beaman, Meagan C Branch, Dennis P Buehler, Simon J Conway, E Michelle Southard-Smith

Open access · greenAbstract read
In one paragraph

Article in Developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Mild features of partialFrontiers in pediatrics · 2025
    Article
  2. Article
  3. Innervation in organogenesis.Current topics in developmental biology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Karen K DealDivision of Genetic Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.
Anoop S ChandrashekarVanderbilt University, Nashville, TN, USA.
M Makenzie BeamanVanderbilt University, Nashville, TN, USA.
Meagan C BranchDivision of Genetic Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.
Dennis P BuehlerDivision of Genetic Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.
Simon J ConwayHB Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA.
E Michelle Southard-SmithDivision of Genetic Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA. Electronic address: michelle.southard-smith@vanderbilt.edu.
Vanderbilt University · USIndiana University School of Medicine

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STACIE B DUSETZINA · 1995 to 2026
$172.8M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
Vanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ALVIN C POWERS · 2012 to 2026
$29.3M
Shop Module CoreP30EY008126 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI David J. Calkins · 1989 to 2026
$19.6M
Vanderbilt Mouse Metabolic Physiology CenterU24DK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2001 to 2015
$14.9M
Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey L Neul · 2020 to 2026
$10.3M
Medical Scientist Training Program Training GrantT32GM145449 · NIGMS · DUKE UNIVERSITY · PI Christopher D Kontos · 2022 to 2026
$6.6M
Neural Crest Contributions to the Lower Urinary TractR01DK078158 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SOUTHARD-SMITH, E MICHELLE · 2007 to 2017
$2.1M
Atlas of autonomic and neuromodulatory lineages in the developing lower urinary tractU01DK110804 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SOUTHARD-SMITH, E MICHELLE · 2016 to 2020
$1.9M
Gene Networks in Neural Crest-derived Innervation of the Lower Urinary TractRC1DK086594 · NIDDK · VANDERBILT UNIVERSITY · PI SOUTHARD-SMITH, E MICHELLE · 2009 to 2010
$738k
LSM880-Airyscan Confocal Microscope for Large Shared ResourceS10OD021630 · OD · VANDERBILT UNIVERSITY · PI WELLS, K. SAM · 2016 to 2016
$560k
NCI NIH HHS P30 CA068485NEI NIH HHS P30 EY008126NICHD NIH HHS P50 HD103537NIDDK NIH HHS P30 DK020593NIDDK NIH HHS P30 DK058404NIDDK NIH HHS R01 DK078158NIDDK NIH HHS RC1 DK086594NIDDK NIH HHS U01 DK110804NIDDK NIH HHS U24 DK059637NIGMS NIH HHS T32 GM145449NIH HHS S10 OD021630
6 · The paper itself

Abstract

Mouse models of Spina bifida (SB) have been instrumental for identifying genes, developmental processes, and environmental factors that influence neurulation and neural tube closure. Beyond the prominent neural tube defects, other aspects of the nervous system can be affected in SB with significant changes in essential bodily functions such as urination. SB patients frequently experience bladder dysfunction and SB fetuses exhibit reduced density of bladder nerves and smooth muscle although the developmental origins of these deficits have not been determined. The Pax3 Splotch-delayed (Pax3

Indexed as

AnimalsCell DifferentiationDisease Models, AnimalFemaleGangliaMaleMiceMice, Inbred C57BLNervous SystemNeural CrestNeural Tube DefectsNeurogenesisPaired Box Transcription FactorsPAX3 Transcription FactorSacrococcygeal RegionSOXE Transcription FactorsPaired Box Transcription FactorsPax3 protein, mousePAX3 Transcription FactorSOXE Transcription FactorsAutonomic nervous systemBladderLower urinary tractPax3Pelvic gangliaSacral neural crest

Identifiers

PMID33839113
PMCPMC8172446
OpenAlexW3145559145

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.