Evidence map›Paper›PMID 33838594›Full record

ArticleDiagnostic microbiology and infectious disease2021

Validation of a diphtheria toxoid multiplex bead assay for serosurveys.

Heather M Scobie, Nino Khetsuriani, Androulla Efstratiou, Jeffrey W Priest

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostic microbiology and infectious disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Heather M ScobieGlobal Immunization Division, Centers for Disease Control and Prevention, Atlanta, GA, USA. Electronic address: vih8@cdc.gov.
Nino KhetsurianiGlobal Immunization Division, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Androulla EfstratiouWorld Health Organization Collaborating Centre for Diphtheria and Streptococcal Infections, Public Health England, London, UK.
Jeffrey W PriestDivision of Foodborne, Waterborne, and Environmental Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

We validated a multiplex bead assay for diphtheria toxoid IgG antibodies against the Vero cell toxin neutralization test using 1300 specimens (correlation = 0.88). At the ≥0.01 IU/mL cutoff for minimal seroprotection, sensitivity was 95% and specificity was 83%. Agreement for three categories (<0.01, 0.01-<0.1, ≥0.1 IU/mL) was 81% (kappa = 0.71).

Indexed as

Diphtheria ToxoidAnimalsAntibodies, BacterialChlorocebus aethiopsImmunoglobulin GNeutralization TestsReproducibility of ResultsSensitivity and SpecificitySerologic TestsVero CellsAntibodies, BacterialDiphtheria ToxoidImmunoglobulin GDiphtheriaImmunityMultiplex assaySerological testSerologySerosurveillance

Identifiers

PMID33838594
PMCPMC10370405

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.