ArticleNeuroImage. Clinical2021
Cortical fractal dimension predicts disability worsening in Multiple Sclerosis patients.
Article in NeuroImage. Clinical, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Synthetic MRI and radiomics in multiple sclerosis: improving precision in diagnosis and prognosis.Radiological physics and technology · 2026Review
- Physical, cognitive, and psychosocial fatigue are differently related to cortical complexity of superior temporal and frontal brain regions in Crohn's disease.Frontiers in neuroimaging · 2026Article
- Fractal dimension as a predictive biomarker for tumor grade and cerebellar mutism syndrome in pediatric posterior fossa tumors.Quantitative imaging in medicine and surgery · 2025Article
- Cortical changes in women with systemic lupus erythematosus with mild cognitive impairment: a voxel-based morphometry and surface-based morphometry study.Lupus science & medicine · 2025Article
- Study of prediction model for high-grade meningioma using fractal geometry combined with radiological features.Journal of neuro-oncology · 2025Article
- T1- and diffusion tensor-based fractal dimension of white and grey matter in multiple sclerosis.Frontiers in neurology · 2025Article
- Fractal Analysis in Neurodegenerative Diseases.Advances in neurobiology · 2024Article
- Fractal Dimension Analysis in Neurological Disorders: An Overview.Advances in neurobiology · 2024Review
- The complexity of cortical folding is reduced in chronic cocaine users.Addiction biology · 2023Article
- Neuroimaging to monitor worsening of multiple sclerosis: advances supported by the grant for multiple sclerosis innovation.Frontiers in neurology · 2023Review
- Development of a predictive model for predicting disability after optic neuritis: a secondary analysis of the Optic Neuritis Treatment Trial.Frontiers in neurology · 2023Article
- Toward an Automatic Assessment of Cognitive Dysfunction in Relapsing-Remitting Multiple Sclerosis Patients Using Eye Movement Analysis.Sensors (Basel, Switzerland) · 2022Article
- Cortical complexity in world trade center responders with chronic posttraumatic stress disorder.Translational psychiatry · 2021Article
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13 authors.
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Abstract
backgroundFractal geometry measures the morphology of the brain and detects CNS damage. We aimed to assess the longitudinal changes on brain's fractal geometry and its predictive value for disease worsening in patients with Multiple Sclerosis (MS).
methodsWe prospectively analyzed 146 consecutive patients with relapsing-remitting MS with up to 5 years of clinical and brain MRI (3 T) assessments. The fractal dimension and lacunarity were calculated for brain regions using box-counting methods. Longitudinal changes were analyzed in mixed-effect models and the risk of disability accumulation were assessed using Cox Proportional Hazard regression analysis.
resultsThere was a significant decrease in the fractal dimension and increases of lacunarity in different brain regions over the 5-year follow-up. Lower cortical fractal dimension increased the risk of disability accumulation for the Expanded Disability Status Scale [HR 0.9734, CI 0.8420-0.9125; Harrell C 0.59; Wald p 0.038], 9-hole peg test [HR 0.9734, CI 0.8420-0.9125; Harrell C 0.59; Wald p 0.0083], 2.5% low contrast vision [HR 0.4311, CI 0.2035-0.9133; Harrell C 0.58; Wald p 0.0403], symbol digit modality test [HR 2.215, CI 1.043-4.705; Harrell C 0.65; Wald p 0.0384] and MS Functional Composite-4 [HR 0.55, CI 0.317-0.955; Harrell C 0.59; Wald p 0.0029].
conclusionsFractal geometry analysis of brain MRI identified patients at risk of increasing their disability in the next five years.
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