Evidence map›Paper›PMID 33838229›Full record

ArticleThe Journal of nutritional biochemistry2021

Olive oil-derived nitro-fatty acids: protection of mitochondrial function in non-alcoholic fatty liver disease.

Beatriz Sánchez-Calvo, Adriana Cassina, Mauricio Mastrogiovanni, Mariela Santos, Emiliano Trias, Eric E Kelley, Homero Rubbo, Andrés Trostchansky

Open access · greenAbstract read
In one paragraph

Article in The Journal of nutritional biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Beatriz Sánchez-CalvoDepartamento de Bioquímica and Centro de Investigaciones Biomédicas (CENIBIO), Facultad de Medicina, Universidad de la República, Montevideo, Uruguay; Departamento de Nutrición Básica, Escuela de Nutrición, Universidad de la República, Montevideo, Uruguay.
Adriana CassinaDepartamento de Bioquímica and Centro de Investigaciones Biomédicas (CENIBIO), Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
Mauricio MastrogiovanniDepartamento de Bioquímica and Centro de Investigaciones Biomédicas (CENIBIO), Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
Mariela SantosUnidad de Reactivos y Biomodelos de Experimentación, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
Emiliano TriasInstitut Pasteur de Montevideo, Montevideo, Uruguay.
Eric E KelleyDepartment of Physiology and Pharmacology, West Virginia University, United States.
Homero RubboDepartamento de Bioquímica and Centro de Investigaciones Biomédicas (CENIBIO), Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
Andrés TrostchanskyDepartamento de Bioquímica and Centro de Investigaciones Biomédicas (CENIBIO), Facultad de Medicina, Universidad de la República, Montevideo, Uruguay. Electronic address: trocha@fmed.edu.uy.
Universidad de la República de Uruguay · UYInstitut Pasteur de Montevideo · UYWest Virginia University · US

Funding

West Virginia University Stroke COBREP20GM109098 · NIGMS · WEST VIRGINIA UNIVERSITY · PI HRUSKA, MARTIN · 2014 to 2024
$24.5M
PROTEOMICSP01AG043376 · NIA · UNIVERSITY OF MINNESOTA · PI ROBBINS, PAUL D. · 2013 to 2019
$11.2M
Targeting Uric Acid as a Therapeutic for NASHR01DK124510 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KELLEY, ERIC EUGENE, KHOO, NICHOLAS · 2020 to 2023
$1.4M
NIA NIH HHS P01 AG043376NIDDK NIH HHS R01 DK124510NIGMS NIH HHS P20 GM109098
6 · The paper itself

Abstract

Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive liver fat deposition in the absence of significant alcohol intake. Since extra virgin olive oil (EVOO) reduces fat accumulation, we analyzed the involvement of nitro-fatty acids (NO

Indexed as

AnimalsBody CompositionBody WeightDietary SupplementsFatty AcidsFemaleGene Expression Regulation, EnzymologicHeme Oxygenase-1LiverMembrane ProteinsMiceMice, Inbred C57BLMitochondriaNon-alcoholic Fatty Liver DiseaseOlive OilOrgan SizeFatty AcidsHeme Oxygenase-1Hmox1 protein, mouseMembrane ProteinsOlive OilCell signalingHigh fat dietMediterranean dietMitochondriaNitroalkenesNon-alcoholic fatty liver diseaseNutrition Liver

Identifiers

PMID33838229
PMCPMC8197755
OpenAlexW3150784240

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.