Evidence map›Paper›PMID 33838045›Full record

ArticleSleep2021

Sleep symptomatology is associated with greater subjective cognitive concerns: findings from the community-based Healthy Brain Project.

Jessica Nicolazzo, Katharine Xu, Alexandra Lavale, Rachel Buckley, Nawaf Yassi, Garun S Hamilton, Paul Maruff, Andree-Ann Baril, Yen Ying Lim, Matthew P Pase

Open access · bronzeAbstract read
In one paragraph

Article in Sleep, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

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  6. Comparison between self-reported and actigraphy-derived sleep measures in patients receiving home parenteral nutrition: Secondary analysis of observational data.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 2 countries.

Jessica NicolazzoThe Turner Institute for Brain and Mental Health, Monash University, Clayton, Victoria, Australia.ORCID 0000-0001-5044-0766
Katharine XuMelbourne School of Psychological Sciences, University of Melbourne, Parkville, Victoria, Australia.
Alexandra LavaleThe Turner Institute for Brain and Mental Health, Monash University, Clayton, Victoria, Australia.
Rachel BuckleyMelbourne School of Psychological Sciences, University of Melbourne, Parkville, Victoria, Australia.ORCID 0000-0002-5356-5537
Nawaf YassiDepartment of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.
Garun S HamiltonMonash Lung and Sleep, Monash Health, Melbourne, Victoria, Australia.
Paul MaruffCogstate Ltd., Melbourne, Victoria, Australia.
Andree-Ann BarilDepartment of Neurology, Boston University School of Medicine, Boston, MA, USA.ORCID 0000-0003-3671-7081
Yen Ying LimThe Turner Institute for Brain and Mental Health, Monash University, Clayton, Victoria, Australia.
Matthew P PaseThe Turner Institute for Brain and Mental Health, Monash University, Clayton, Victoria, Australia.
Monash University · AUBoston University · USBrigham and Women's Hospital · USFlorey Institute of Neuroscience and Mental Health · AUHarvard University · USMonash Health · AUThe Royal Melbourne Hospital · AUThe University of Melbourne · AU

Funding

Contributions of sleep to preclinical and clinical Alzheimer's diseaseR01AG062531 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI HIMALI, JAYANDRA JUNG, PASE, MATTHEW · 2020 to 2023
$3.1M
Elucidating the mechanisms underlying sex differences in cognitive decline due to preclinical Alzheimer's diseaseK99AG061238 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI BUCKLEY, RACHEL FRANCES · 2019 to 2020
$273k
NIA NIH HHS K99 AG061238NIA NIH HHS R01 AG062531Wellcome Trust 102052
6 · The paper itself

Abstract

STUDY

objectivesTo examine if sleep symptomatology was associated with subjective cognitive concerns or objective cognitive performance in a dementia-free community-based sample.

methodsA total of 1,421 middle-aged participants (mean ± standard deviation = 57 ± 7; 77% female) from the Healthy Brain Project completed the Pittsburgh Sleep Quality Index, Insomnia Severity Index, and Epworth Sleepiness Scale to measure sleep quality, insomnia symptom severity, and daytime sleepiness, respectively. Participants were classified as having no sleep symptomatology (normal scores on each sleep measure), moderate sleep symptomatology (abnormal scores on one sleep measure), or high sleep symptomatology (abnormal scores on at least two sleep measures), using established cutoff values. Analysis of covariance was used to compare objective cognitive function (Cogstate Brief Battery) and subjective cognitive concerns (Modified Cognitive Function Instrument) across groups.

resultsFollowing adjustments for age, sex, education, mood, and vascular risk factors, persons classified as having high sleep symptomatology, versus none, displayed more subjective cognitive concerns (d = 0.24) but no differences in objective cognitive performance (d = 0.00-0.18). Subjective cognitive concerns modified the association between sleep symptomatology and psychomotor function. The strength of the relationship between high sleep symptomatology (versus none) and psychomotor function was significantly greater in persons with high as compared with low cognitive concerns (β ± SE = -0.37 ± 0.16; p = 0.02).

conclusionsMore severe sleep symptomatology was associated with greater subjective cognitive concerns. Persons reporting high levels of sleep symptomatology may be more likely to display poorer objective cognitive function in the presence of subjective cognitive concerns.

Indexed as

Sleep Initiation and Maintenance DisordersSleep Wake DisordersBrainCognitionFemaleHumansMaleMiddle AgedSleepAlzheimer’s diseasecognitioncognitive performancedaytime sleepinessdementiainsomniasleepsleep quality

Identifiers

PMID33838045
PMCPMC8436141
OpenAlexW3143952273

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.