Evidence map›Paper›PMID 33837991›Full record

ArticleNeurogastroenterology and motility2021

Bicarbonate ion transport by the electrogenic Na

Wenchang Zhao, Liwen Zhang, Leonid G Ermilov, Maria Gabriela Colmenares Aguilar, David R Linden, Seth T Eisenman, Michael F Romero, Gianrico Farrugia, Lei Sha, Simon J Gibbons

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurogastroenterology and motility, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Wenchang ZhaoEnteric Neuroscience Program, Division of Gastroenterology and Hepatology, Rochester, MN, USA.
Liwen ZhangEnteric Neuroscience Program, Division of Gastroenterology and Hepatology, Rochester, MN, USA.
Leonid G ErmilovEnteric Neuroscience Program, Division of Gastroenterology and Hepatology, Rochester, MN, USA.
Maria Gabriela Colmenares AguilarEnteric Neuroscience Program, Division of Gastroenterology and Hepatology, Rochester, MN, USA.
David R LindenEnteric Neuroscience Program, Division of Gastroenterology and Hepatology, Rochester, MN, USA.ORCID 0000-0002-1727-0387
Seth T EisenmanEnteric Neuroscience Program, Division of Gastroenterology and Hepatology, Rochester, MN, USA.
Michael F RomeroPhysiology and Biomedical Engineering, Rochester, MN, USA.
Gianrico FarrugiaEnteric Neuroscience Program, Division of Gastroenterology and Hepatology, Rochester, MN, USA.
Lei ShaNeuroendocrine Pharmacology, China Medical University, Shenyang, China.
Simon J GibbonsEnteric Neuroscience Program, Division of Gastroenterology and Hepatology, Rochester, MN, USA.ORCID 0000-0001-5311-5993
University of Minnesota Rochester · USChina Medical University · CNMayo Clinic · US

Funding

PILOT AND FEASIBILTY PROGRAMP30DK084567 · NIDDK · MAYO CLINIC ROCHESTER · PI Samar Ibrahim · 2009 to 2026
$22.2M
CALCIUM DYNAMICS IN INTERSTITIAL CELLS OF CAJALR01DK057061 · NIDDK · MAYO CLINIC ROCHESTER · PI GIANRICO FARRUGIA, Tamas Ordog · 2000 to 2026
$8.2M
NIDDK NIH HHS P30 DK084567NIDDK NIH HHS R01 DK057061
6 · The paper itself

Abstract

backgroundNormal gastrointestinal motility depends on electrical slow-wave activity generated by interstitial cells of Cajal (ICC) in the tunica muscularis of the gastrointestinal tract. A requirement for HCO

methodsImmunohistochemistry and sharp electrode electrical recordings were used. KEY

resultsThe NBCe1 immunoreactivity was localized to ICC-MY of the tunica muscularis. In sharp electrode electrical recordings, removal of HCO CONCLUSIONS & INFERENCES: These studies demonstrate a major role for Na

Indexed as

AnimalsBicarbonatesFemaleGastrointestinal MotilityIntestine, SmallIon TransportMaleMiceMice, Inbred C57BLSodium-Bicarbonate SymportersBicarbonatesSodium-Bicarbonate Symportersbiological pacemakersgastrointestinal motilityinterstitial cells of CajalmouseSlc4a4 proteinsmall intestinesmooth muscle

Identifiers

PMID33837991
PMCPMC8485339
OpenAlexW3142899000

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.