ArticleBiological trace element research2022
Association Between Low-Level Blood Cadmium Exposure and Hyperuricemia in the American General Population: a Cross-sectional Study.
Article in Biological trace element research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- A systematic review and meta-analysis of the hyperuricemia risk from certain metals.Clinical rheumatology · 2022Pooled it
- Current Understanding of Sex Differences in Metal-Induced Diseases.Current environmental health reports · 2025Review
- Estimation of Hair Toxic and Essential Trace Element and Mineral Profiles of Patients with Chronic Gout.Biological trace element research · 2025Article
- Association between vitamin B1 intake and hyperuricemia in adults.Scientific reports · 2024Article
- Blood Lead Mediates the Relationship between Biological Aging and Hypertension: Based on the NHANES Database.Nutrients · 2024Article
- Association between exposure to a mixture of organochlorine pesticides and hyperuricemia in U.S. adults: A comparison of four statistical models.Eco-Environment & Health · 2024Article
- Association and mediation analyses among multiple metal exposure, mineralocorticoid levels, and serum ion balance in residents of northwest China.Scientific reports · 2024Article
- Review
- Association and Interaction between Heavy Metals and Hyperuricemia in a Taiwanese Population.Diagnostics (Basel, Switzerland) · 2023Article
- Estimation of health risks associated with dietary cadmium exposure.Archives of toxicology · 2023Review
- High manganese and nickel concentrations in human hair and well water and low calcium concentration in blood serum in a pristine area with sulphide-rich bedrock.Environmental geochemistry and health · 2022Article
- Recent advances in the application of ionomics in metabolic diseases.Frontiers in nutrition · 2022Review
- Associations of metal exposure with hyperuricemia and gout in general adults.Frontiers in endocrinology · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heavy metals, including cadmium, are suspected to increase serum uric acid levels and hyperuricemia in both gender, but the evidences about this are inconclusive. To determine whether serum cadmium in American adults(≥19 years old) is associated with uric acid levels and risk of hyperuricemia, 2620 participants from the US National Health and Nutrition Examination Survey were recruited. Hyperuricemia was defined as a serum UA concentration ≥ 416.4 μmol/L for men and ≥ 356.9 μmol/L for women. Regression analyses were used to analyze the association of cadmium with serum UA and hyperuricemia. The threshold effect explored using two-piecewise linear regression model by the smoothing plot. The overall median of blood cadmium was 0.27 μg/L in men and 0.33μg/L in women. After adjusting for the covariates (race; age; education; BMI; smoke status; alcohol consumption; blood lead; hypertension; diabetes mellitus; hemoglobin; eGFR; triglyceride; and cholesterol), a non-linear relationship between hyperuricemia and cadmium among men was detected; and there was a positive line correlation between them for women (OR = 1.58; 95%CI (1.08, 2.31)). No significant association between uric acid and cadmium in either gender was found. Blood cadmium levels in the range currently considered acceptable were positively associated with increased prevalence of hyperuricemia in women, but inversely associated in men (cadmium <0.77μg/L).
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