ArticleAmino acids2021
Thiazole-amino acids: influence of thiazole ring on conformational properties of amino acid residues.
Article in Amino acids, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 12 citations in OpenAlex.
- Azole γ-Peptides Helix Switching via Heterocycle Substitutions.Angewandte Chemie (International ed. in English) · 2026Article
- 1st generation 1,2,3-triazole based dendrimers with arylmethyl Meldrum's acid surface groups - synthesis and radical scavenging activity.RSC advances · 2026Article
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- Redirecting RiPP Biosynthetic Enzymes to Proteins and Backbone-Modified Substrates.ACS central science · 2022Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
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Abstract
Post-translational modified thiazole-amino acid (Xaa-Tzl) residues have been found in macrocyclic peptides (e.g., thiopeptides and cyanobactins), which mostly inhibit protein synthesis in Gram + bacteria. Conformational study of the series of model compounds containing this structural motif with alanine, dehydroalanine, dehydrobutyrine and dehydrophenylalanine were performed using DFT method in various environments. The solid-state crystal structure conformations of thiazole-amino acid residues retrieved from the Cambridge Structural Database were also analysed. The studied structural units tend to adopt the unique semi-extended β2 conformation; which is stabilised mainly by N-H⋯N
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