Evidence map›Paper›PMID 33837696›Full record

ArticleCurrent topics in membranes2020

The interplay of membrane cholesterol and substrate on vascular smooth muscle biomechanics.

Hanna J Sanyour, Alex P Rickel, Zhongkui Hong

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current topics in membranes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Hanna J SanyourDepartment of Biomedical Engineering, University of South Dakota, Vermillion, SD, United States.
Alex P RickelDepartment of Biomedical Engineering, University of South Dakota, Vermillion, SD, United States.
Zhongkui HongDepartment of Biomedical Engineering, University of South Dakota, Vermillion, SD, United States. Electronic address: zhongkui.hong@usd.edu.
University of South Dakota · US

Funding

Mechanical Response and Cytoskeletal Rearrangement Following Interrupted Cholesterol Metabolism in Vascular Smooth Muscle CellR15HL147214 · NHLBI · UNIVERSITY OF SOUTH DAKOTA · PI HONG, ZHONGKUI · 2020 to 2020
$429k
NHLBI NIH HHS R15 HL147214
6 · The paper itself

Abstract

Cardiovascular disease (CVD) remains the primary cause of death worldwide. Specifically, atherosclerosis is a CVD characterized as a slow progressing chronic inflammatory disease. During atherosclerosis, vascular walls accumulate cholesterol and cause fatty streak formation. The progressive changes in vascular wall stiffness exert alternating mechanical cues on vascular smooth muscle cells (VSMCs). The detachment of VSMCs in the media layer of the vessel and migration toward the intima is a critical step in atherosclerosis. VSMC phenotypic switching is a complicated process that modifies VSMC structure and biomechanical function. These changes affect the expression and function of cell adhesion molecules, thus impacting VSMC migration. Accumulating evidence has shown cholesterol is capable of regulating cellular migration, proliferation, and spreading. However, the interaction and coordinated effects of both cellular cholesterol and the extracellular matrix (ECM) stiffness/composition on VSMC biomechanics remains to be elucidated.

Indexed as

Muscle, Smooth, VascularMyocytes, Smooth MuscleBiomechanical PhenomenaCell MovementCells, CulturedCholesterolCholesterolAtherosclerosisAtomic force microscopyCell mechanicsCholesterolCytoskeletonSubstrate stiffnessVascular smooth muscle cells

Identifiers

PMID33837696
PMCPMC8041049
OpenAlexW3091610939

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.