Evidence map›Paper›PMID 33837454›Full record

ArticleEuropean biophysics journal : EBJ2021

Analysis of patchclamp recordings: model-free multiscale methods and software.

Florian Pein, Benjamin Eltzner, Axel Munk

Abstract read
In one paragraph

Article in European biophysics journal : EBJ, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Electromechanically induced membrane restructuring enables learning and memory.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Florian PeinStatistical Laboratory, DPMMS, University of Cambridge, Cambridge, UK. fpein@maths.cam.ac.uk.ORCID http://orcid.org/0000-0002-7994-9264
Benjamin EltznerInstitute for Mathematical Stochastics, Georg-August-University of Goettingen, Göttingen, Germany.
Axel MunkInstitute for Mathematical Stochastics, Georg-August-University of Goettingen, Göttingen, Germany.

Funding

Deutsche Forschungsgemeinschaft Cluster of excellence 2067Deutsche Forschungsgemeinschaft SFB803 - Z02Engineering and Physical Sciences Research Council EP/N031938/1Volkswagen Foundation FBMS
6 · The paper itself

Abstract

Analysis of patchclamp recordings is often a challenging issue. We give practical guidance how such recordings can be analyzed using the model-free multiscale idealization methodology JSMURF, JULES, and HILDE. We provide an operational manual how to use the accompanying software available as an R-package and as a graphical user interface. This includes selection of the right approach and tuning of parameters. We also discuss advantages and disadvantages of model-free approaches in comparison to hidden Markov model approaches and explain how they complement each other.

Indexed as

SoftwareMarkov ChainsPatch-Clamp TechniquesDeconvolutionFlickeringFully automaticHidden Markov modelsHomogeneous and heterogeneous noiseIon channel recordingsLow-pass filteringOpen-channel noisePorBSubconductance states

Identifiers

PMID33837454
PMCPMC8071803

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.