Evidence map›Paper›PMID 33837437›Full record

ArticleALTEX2021

Applying evidence-based methods to the development and use of adverse outcome pathways

Rob B M De Vries, Michelle Angrish, Patience Browne, Jan Brozek, Andrew A Rooney, Daniele S Wikoff, Paul Whaley, Stephen W Edwards, Rebecca L Morgan, Ingrid L Druwe and 17 more

Abstract readEditorial
PubMed Full text at PMC Publisher
In one paragraph

Article in ALTEX, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Rob B M De VriesEvidence-Based Toxicology Collaboration (EBTC) at Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Michelle AngrishUnited States Environmental Protection Agency, Office of Research and Development, Center for Public Health and Environmental Assessments, Research Triangle Park, NC, USA.
Patience BrowneTest Guidelines Programme, Environmental Directorate, OECD, Paris, France.
Jan BrozekDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
Andrew A RooneyDivision of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Daniele S WikoffToxStrategies, Asheville, NC, USA.
Paul WhaleyEvidence-Based Toxicology Collaboration (EBTC) at Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Stephen W EdwardsRTI International, Research Triangle Park, NC, USA.
Rebecca L MorganDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
Ingrid L DruweUnited States Environmental Protection Agency, Office of Research and Development, Center for Public Health and Environmental Assessments, Research Triangle Park, NC, USA.
Sebastian HoffmannEvidence-Based Toxicology Collaboration (EBTC) at Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Thomas HartungCenter for Alternatives to Animal Testing (CAAT) at Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Kristina ThayerUnited States Environmental Protection Agency, Office of Research and Development, Center for Public Health and Environmental Assessments, Research Triangle Park, NC, USA.
Marc T AveyICF, Durham, NC, USA.
Brandiese E J BeverlyDivision of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Maicon FalavignaDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
Catherine GibbonsUnited States Environmental Protection Agency, Office of Research and Development, Center for Public Health and Environmental Assessments, Research Triangle Park, NC, USA.
Katy GoyakExxonMobil Biomedical Sciences Inc., Annandale, NJ, USA.
Andrew KraftUnited States Environmental Protection Agency, Office of Research and Development, Center for Public Health and Environmental Assessments, Research Triangle Park, NC, USA.
Fernando NampoEvidence-Based Public Health Research Group, Latin-American Institute of Life and Nature Sciences, Federal University of Latin-American Integration, Foz do Iguassu, Parana, Brazil.
Amir QaseemCenter for Evidence Reviews, The American College of Physicians, Philadelphia, PA, USA.
Meg SearsCanadian Environmental Health Information Infrastructure, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Jasvinder A SinghMedicine Service, VA Medical Center, Birmingham, AL, USA; Department of Medicine at the School of Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL, USA; and Department of Epidemiology at the UAB School of Public Health, Birmingham, AL, USA.
Catherine WillettHumane Society International, Washington, DC, USA.
Erin Y YostUnited States Environmental Protection Agency, Office of Research and Development, Center for Public Health and Environmental Assessments, Research Triangle Park, NC, USA.
Holger SchünemannDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
Katya TsaiounEvidence-Based Toxicology Collaboration (EBTC) at Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Funding

Integrated Health Assessments for the Division of the National Toxicology ProgramZICES103317 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI ROONEY, ANDREW · 2020 to 2021
$9.6M
Intramural NIH HHS Z99 ES999999
6 · The paper itself

Abstract

The workshop “Application of evidence-based methods to construct mechanistic frameworks for the development and use of non-animal toxicity tests” was organized by the Evidence-based Toxicology Collaboration and hosted by the Grading of Recommendations Assessment, Development and Evaluation Working Group on June 12, 2019. The purpose of the workshop was to bring together international regulatory bodies, risk assessors, academic scientists, and industry to explore how systematic review methods and the adverse outcome pathway framework could be combined to develop and use mechanistic test methods for predicting the toxicity of chemical substances in an evidence-based manner. The meeting covered the history of biological frameworks, the way adverse outcome pathways are currently developed, the basic principles of systematic methodology, including systematic reviews and evidence maps, and assessment of cer­tainty in models, and adverse outcome pathways in particular. Specific topics were discussed via case studies in small break-out groups. The group concluded that adverse outcome pathways provide an important framework to support mechanism-based assessment in environmental health. The process of their development has a few challenges that could be addressed with systematic methods and automation tools. Addressing these challenges will increase the transparency of the evidence behind adverse outcome pathways and the consistency with which they are defined; this in turn will increase their value for supporting public health decisions. It was suggested to explore the details of applying systematic methods to adverse outcome pathway development in a series of case studies and workshops.

Indexed as

Adverse Outcome PathwaysResearch DesignToxicity Testsadverse outcome pathwayevidence-basednon-animal methodrisk assessmentsystematic review

Identifiers

PMID33837437
PMCPMC9394185

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.