Evidence map›Paper›PMID 33837380›Full record

Trial reportThe British journal of surgery2021

Supervised exercise after oesophageal cancer surgery: the PERFECT multicentre randomized clinical trial.

J K van Vulpen, A E Hiensch, R van Hillegersberg, J P Ruurda, F J G Backx, G A P Nieuwenhuijzen, E A Kouwenhoven, R P R Groenendijk, D L van der Peet, E J Hazebroek and 6 more

2 registry-linked trialsOpen access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The British journal of surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 19 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 8 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06138223 narecruitingnot on this mapstarted 2024, after this paper: background citation

The Effect of exeRcise And Diet on Quality of Life in Patients With Incurable Cancer of Esophagus and Stomach (RADICES)

TypeinterventionalSponsorAcademisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)Ran2024 to 2028Enrolled196ConditionsGastroEsophageal Cancer, Incurable DiseaseArmsExercise intervention, Nutrition intervention
NCT06366685 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Development and Initial Application of a Combined Exercise and Psychological Intervention Program for Patients After Esophagectomy

TypeinterventionalSponsorMengmeng YuanRan2024 to 2025Enrolled60ConditionsEsophageal Cancer, Exercise Training, Psychotherapy, RehabilitationArmsExercise and Psychological Intervention
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 8 syntheses or guidelines pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Physical activity and pain in people with cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
  7. Pooled it
  8. Pooled it
  9. Trial
  10. Trial
  11. Perceived facilitators and barriers by esophageal cancer survivors participating in a post-treatment exercise program.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Trial
  12. In-hospital moderate intensity interval training following surgical resection of foregut malignancy - a prospective single arm feasibility study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  13. Observational
  14. Review
  15. Trajectory of change in symptom patterns among patients undergoing surgery for oesophageal cancer: a prospective longitudinal study using latent transition analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  16. Article
  17. Review
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 1 country.

J K van VulpenJulius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.
A E HienschJulius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.
R van HillegersbergDepartment of Surgery, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.
J P RuurdaDepartment of Surgery, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.
F J G BackxDepartment of Rehabilitation, Physical Therapy Science & Sport, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.
G A P NieuwenhuijzenDepartment of Surgery, Catharina Hospital, Eindhoven, The Netherlands.ORCID 0000-0002-5837-5513
E A KouwenhovenDepartment of Surgery, ZGT Hospital, Almelo, The Netherlands.
R P R GroenendijkDepartment of Surgery, IJsselland Hospital, Capelle a/d IJssel, The Netherlands.
D L van der PeetDepartment of Surgery, Cancer Centre Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
E J HazebroekDepartment of Surgery, Rijnstate Hospital, Arnhem, The Netherlands.
C RosmanDepartment of Surgery, Radboud University Medical Centre, Nijmegen, The Netherlands.ORCID 0000-0002-9152-3987
B P L WijnhovenDepartment of Surgery, Erasmus University Medical Centre, Rotterdam, The Netherlands.
M I van Berge HenegouwenDepartment of Surgery, Cancer Centre Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0001-8689-3134
H W M van LaarhovenDepartment of Medical Oncology, Cancer Centre Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
P D SiersemaDepartment of Gastroenterology and Hepatology, Radboud University Medical Centre, Nijmegen, The Netherlands.
A M MayJulius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.
Utrecht University · NLAmsterdam University Medical Centers · NLRadboud University Nijmegen · NLErasmus University Rotterdam · NLIJsselland Ziekenhuis · NLRijnstate Hospital · NLZiekenhuis Groep Twente · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study investigated whether a supervised exercise programme improves quality of life (QoL), fatigue and cardiorespiratory fitness in patients in the first year after oesophagectomy.

methodsThe multicentre PERFECT trial randomly assigned patients to an exercise intervention (EX) or usual care (UC) group. EX patients participated in a 12-week moderate- to high-intensity aerobic and resistance exercise programme supervised by a physiotherapist. Primary (global QoL, QoL summary score) and secondary (QoL subscales, fatigue and cardiorespiratory fitness) outcomes were assessed at baseline, 12 and 24 weeks and analysed as between-group differences using either linear mixed effects models or ANCOVA.

resultsA total of 120 patients (mean(s.d.) age 64(8) years) were included and randomized to EX (61 patients) or UC (59 patients). Patients in the EX group participated in 96 per cent (i.q.r. 92-100 per cent) of the exercise sessions and the relative exercise dose intensity was high (92 per cent). At 12 weeks, beneficial EX effects were found for QoL summary score (3.5, 95 per cent c.i. 0.2 to 6.8) and QoL role functioning (9.4, 95 per cent c.i. 1.3 to 17.5). Global QoL was not statistically significant different between groups (3.0, 95 per cent c.i. -2.2 to 8.2). Physical fatigue was lower in the EX group (-1.2, 95 per cent c.i. -2.6 to 0.1), albeit not significantly. There was statistically significant improvement in cardiorespiratory fitness following EX compared with UC (peak oxygen uptake (1.8 ml/min/kg, 95 per cent c.i. 0.6 to 3.0)). After 24 weeks, all EX effects were attenuated.

conclusionsA supervised exercise programme improved cardiorespiratory fitness and aspects of QoL.

trial registrationDutch Trial Register NTR 5045 (www.trialregister.nl/trial/4942).

Indexed as

Neoplasm StagingQuality of LifeEsophageal NeoplasmsEsophagectomyExercise TherapyFemaleFollow-Up StudiesHumansMaleMiddle AgedRetrospective StudiesTreatment Outcome

Identifiers

PMID33837380
PMCPMC10364897
OpenAlexW3143014582

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.