ArticleBritish journal of cancer2021
Genetically predicted circulating B vitamins in relation to digestive system cancers.
Article in British journal of cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
12 citing papers in PubMed, 14 citations in OpenAlex.
- B vitamins intake and cancer risk: a structured narrative review of evidence on riboflavin, pyridoxine, cobalamin and folate.Pathology oncology research : POR · 2026Review
- Folate Attenuates Ulcerative Colitis via PI3K/AKT/NF-κB/MLCK Axis Inhibition to Restore Intestinal Barrier Integrity.Biology · 2025Article
- Genetically proxied risk and protective factors for pancreatic cancer: a systematic review and meta-analysis of Mendelian randomization studies.Journal of gastrointestinal oncology · 2025Article
- Understanding the Genetic Architecture of Vitamin Status Biomarkers in the Genome-Wide Association Study Era: Biological Insights and Clinical Significance.Advances in nutrition (Bethesda, Md.) · 2024Review
- The Role of Dietary Vitamins and Antioxidants in Preventing Colorectal Cancer: A Systematic Review.Cureus · 2024Review
- Mendelian randomisation analysis for intestinal disease: achievement and future.eGastroenterology · 2024Review
- Scientific opinion on the tolerable upper intake level for folate.EFSA journal. European Food Safety Authority · 2023Article
- Role of endogenous and exogenous antioxidants in risk of six cancers: evidence from the Mendelian randomization study.Frontiers in pharmacology · 2023Article
- Bi-directional causal effect between vitamin B12 and non-alcoholic fatty liver disease: Inferring from large population data.Frontiers in nutrition · 2023Article
- Associations of Genetically Predicted Vitamin BNutrients · 2022Article
- Cardiometabolic, Lifestyle, and Nutritional Factors in Relation to Varicose Veins: A Mendelian Randomization Study.Journal of the American Heart Association · 2021Article
- Homocysteine, B vitamins, and cardiovascular disease: a Mendelian randomization study.BMC medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundFolate, vitamin B6 and vitamin B12 have been associated with digestive system cancers. We conducted a two-sample Mendelian randomisation study to assess the causality of these associations.
methodsTwo, one and 14 independent single nucleotide polymorphisms associated with serum folate, vitamin B6 and vitamin B12 at the genome-wide significance threshold were selected as genetic instruments. Summary-level data for the associations of the vitamin-associated genetic variants with cancer were obtained from the UK Biobank study including 367,561 individuals and FinnGen consortium comprising up to 176,899 participants.
resultsGenetically predicted folate and vitamin B6 concentrations were not associated with overall cancer, overall digestive system cancer or oesophageal, gastric, colorectal or pancreatic cancer. Genetically predicted vitamin B12 concentrations were positively associated with overall digestive system cancer (OR
conclusionsThese results provide evidence to suggest that elevated serum vitamin B12 concentrations are associated with colorectal cancer.
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Registered trials
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