Evidence map›Paper›PMID 33837289›Full record

ArticleNature cell biology2021

Depletion of aneuploid cells in human embryos and gastruloids.

Min Yang, Tiago Rito, Jakob Metzger, Jeffrey Naftaly, Rohan Soman, Jianjun Hu, David F Albertini, David H Barad, Ali H Brivanlou, Norbert Gleicher

Erratum issuedOpen access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Nature cell biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 96 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 1 pooled it
40.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 1 synthesis or guideline pooled it, 164 citations in OpenAlex.

  1. Pooled it
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  9. Morphogen Gradients as Drivers of Mosaicism During Early Human Development.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
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36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Min Yang *Laboratory of Stem Cell Biology and Molecular Embryology, The Rockefeller University, New York, NY, USA.
Tiago Rito *Laboratory of Stem Cell Biology and Molecular Embryology, The Rockefeller University, New York, NY, USA.
Jakob MetzgerLaboratory of Stem Cell Biology and Molecular Embryology, The Rockefeller University, New York, NY, USA.
Jeffrey NaftalyLaboratory of Stem Cell Biology and Molecular Embryology, The Rockefeller University, New York, NY, USA.
Rohan SomanLaboratory of Stem Cell Biology and Molecular Embryology, The Rockefeller University, New York, NY, USA.
Jianjun HuThe Center for Human Reproduction, New York, NY, USA.
David F AlbertiniThe Center for Human Reproduction, New York, NY, USA.ORCID http://orcid.org/0000-0001-7182-833X
David H BaradThe Center for Human Reproduction, New York, NY, USA.
Ali H BrivanlouLaboratory of Stem Cell Biology and Molecular Embryology, The Rockefeller University, New York, NY, USA. brvnlou@rockefeller.edu.ORCID http://orcid.org/0000-0002-1761-280X
Norbert GleicherLaboratory of Stem Cell Biology and Molecular Embryology, The Rockefeller University, New York, NY, USA. ngleicher@thechr.com.ORCID http://orcid.org/0000-0002-0202-4167
Rockefeller University · USCenter for Human Reproduction · USFoundation for Reproductive Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chromosomal instability leading to aneuploidy is pervasive in early human embryos

Indexed as

AneuploidyBiopsyBlastocystBone Morphogenetic Protein 4Chromosomal InstabilityChromosomesEmbryo ImplantationEmbryo, MammalianFemaleFertilization in VitroHumansInfertilityMosaicismPregnancyBMP4 protein, humanBone Morphogenetic Protein 4

Identifiers

PMID33837289
OpenAlexW3139736334

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.