ArticleScience advances2021
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Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
8.2field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
66 citing papers in PubMed, 90 citations in OpenAlex.
- Two dipeptide repeat proteins are produced from mammalian telomeric RNA previously thought to be a long non-coding RNA.RNA biology · 2026Review
- Astrocytes regulate axonal mitochondrial transport deficits in C9ORF72 amyotrophic lateral sclerosis motor neurons.Nature neuroscience · 2026Article
- Using human 3D organoid models to gain mechanistic insight in motor neuron diseases.Nature reviews. Neuroscience · 2026Review
- Traffic Jams in the Brain: How Kinesin Dysfunction Shapes Neurodevelopmental Disorders.Current issues in molecular biology · 2026Review
- A next-generation HDAC6 inhibitor for amyotrophic lateral sclerosis and frontotemporal dementia.Brain : a journal of neurology · 2026Article
- Dysregulated neuronal mRNA transport and translation in FTD/ALS.NPJ dementia · 2026Review
- Amyotrophic Lateral Sclerosis: Focus on Cytoplasmic Trafficking and Proteostasis.Molecular neurobiology · 2025Review
- Single-cell RNA-sequencing reveals early mitochondrial dysfunction unique to motor neurons shared across FUS- and TARDBP-ALS.Nature communications · 2025Article
- C21ORF2 mutations point towards primary cilia dysfunction in amyotrophic lateral sclerosis.Brain : a journal of neurology · 2025Article
- Amyotrophic lateral sclerosis caused by hexanucleotide repeat expansions in C9orf72: from genetics to therapeutics.The Lancet. Neurology · 2025Review
- Studying C9orf72 dipeptide repeat polypeptide aggregation using an analytical ultracentrifuge equipped with fluorescence detection.Analytical biochemistry · 2025Article
- Pharmacological effects, molecular mechanisms and strategies to improve bioavailability of curcumin in the treatment of neurodegenerative diseases.Frontiers in pharmacology · 2025Review
- The role of autophagy in the pathogenesis and treatment of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).Autophagy reports · 2025Review
- Analysis of short tandem repeats linked to polyglutamine diseases from whole-genome sequencing reveals intermediate alleles ofBrain communications · 2025Article
- Review
- C9orf72-linked arginine-rich dipeptide repeats aggravate pathological phase separation of G3BP1.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Mechanism-free repurposing of drugs for C9orf72-related ALS/FTD using large-scale genomic data.Cell genomics · 2024Article
- Axonopathy Underlying Amyotrophic Lateral Sclerosis: Unraveling Complex Pathways and Therapeutic Insights.Neuroscience bulletin · 2024Review
- A pathogenic mutation in the ALS/FTD gene VCP induces mitochondrial hypermetabolism by modulating the permeability transition pore.Acta neuropathologica communications · 2024Article
- A force-sensitive mutation reveals a non-canonical role for dynein in anaphase progression.The Journal of cell biology · 2024Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors at 12 institutions in 5 countries.
Laura FumagalliKU Leuven-University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), Leuven, Belgium.ORCID 0000-0002-9333-926X
Florence L YoungDivision of Cell Biology, MRC Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0002-5475-9835
Steven BoeynaemsDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-9705-9871
Mathias De DeckerKU Leuven-University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), Leuven, Belgium.
Arpan R MehtaUK Dementia Research Institute, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-5715-5025
Ann SwijsenKU Leuven-University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), Leuven, Belgium.
Raheem FazalKU Leuven-University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), Leuven, Belgium.ORCID 0000-0001-8833-9997
Wenting GuoKU Leuven-University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), Leuven, Belgium.ORCID 0000-0003-3585-7728
Matthieu MoisseKU Leuven-University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), Leuven, Belgium.ORCID 0000-0001-8880-9311
Jimmy BeckersKU Leuven-University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), Leuven, Belgium.
Lieselot DedeeneKU Leuven-University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), Leuven, Belgium.ORCID 0000-0003-0545-8072
Bhuvaneish T SelvarajUK Dementia Research Institute, University of Edinburgh, Edinburgh, UK.ORCID 0000-0001-7299-0910
Tijs VandoorneKU Leuven-University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), Leuven, Belgium.
Vanesa MadanDivision of Cell Biology, MRC Laboratory of Molecular Biology, Cambridge, UK.
Marka van BlitterswijkDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.ORCID 0000-0002-3054-7053
Denitza RaitchevaBiogen Idec, Boston, MA, USA.ORCID 0000-0001-9003-9168
Alexander McCampbellBiogen Idec, Boston, MA, USA.ORCID 0000-0002-1984-6052
Koen PoesenKU Leuven-University of Leuven, Department of Neurosciences, Laboratory for Molecular Neurobiomarker Research and Leuven Brain Institute (LBI), Leuven, Belgium.
Aaron D GitlerDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-8603-1526
Philipp KochHector Institute for Translational Brain Research, Central Institute of Mental Health, University of Heidelberg, Heidelberg, Germany.ORCID 0000-0003-3713-8786
Pieter Vanden BergheKU Leuven-University of Leuven, Translational Research Centre for Gastrointestinal Disorders, Leuven, Belgium.ORCID 0000-0002-0009-2094
Dietmar Rudolf ThalKU Leuven-University of Leuven, Department of Imaging and Pathology, Laboratory for Neuropathology and Leuven Brain Institute (LBI), Leuven, Belgium.ORCID 0000-0002-1036-1075
Catherine VerfaillieKU Leuven-University of Leuven, Department of Development and Regeneration, Stem Cell Institute, Leuven, Belgium.ORCID 0000-0001-7564-4079
Siddharthan ChandranUK Dementia Research Institute, University of Edinburgh, Edinburgh, UK.
Ludo Van Den BoschKU Leuven-University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), Leuven, Belgium.ORCID 0000-0003-0104-4067
Simon L BullockDivision of Cell Biology, MRC Laboratory of Molecular Biology, Cambridge, UK. philip.vandamme@uzleuven.be sbullock@mrc-lmb.cam.ac.uk.ORCID 0000-0001-9491-4548
Philip Van DammeKU Leuven-University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), Leuven, Belgium. philip.vandamme@uzleuven.be sbullock@mrc-lmb.cam.ac.uk.ORCID 0000-0002-4010-2357
VIB-KU Leuven Center for Brain & Disease Research · BEAllen Institute for Brain Science · USMRC Laboratory of Molecular Biology · GBBiogen (United States) · USRega Institute for Medical Research · BEStanford University · USHeidelberg University · DEInstitute for Stem Cell Biology and Regenerative Medicine · INKU Leuven · BEMayo Clinic in Florida · USMRC Centre for Regenerative Medicine · GBUK Dementia Research Institute · GB
Funding
Medical Research Council MC_U105178790Medical Research Council MR/L023784/2Medical Research Council MR/R001162/1Motor Neurone Disease Association MEHTA/JUL17/948-795
Abstract
A hexanucleotide repeat expansion in the
Indexed as
Amyotrophic Lateral SclerosisFrontotemporal DementiaAnimalsArginineAxonal TransportC9orf72 ProteinDipeptidesDNA Repeat ExpansionDrosophilaHumansMicrotubulesMotor NeuronsArginineC9orf72 ProteinC9orf72 protein, humanDipeptides
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.