ArticleScience advances2021
Ketogenic diet reduces alcohol withdrawal symptoms in humans and alcohol intake in rodents.
Registry-linked trialOpen access · goldAbstract read
In one paragraph
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03255031 (Ketogenic Diet), which is not on this map. Cited by 43 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
7.1field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Ketogenic Diet (KD) in Alcoholism
Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- An Overview of Appetite-Regulatory Peptides in Addiction Processes; From Bench to Bed Side.Frontiers in neuroscience · 2021Pooled it
- Pharmacokinetic effects of a single dose nutritional ketone ester supplement on brain glucose and ketone metabolism in alcohol use disorder.Psychiatry research. Neuroimaging · 2026Trial
- A randomized feasibility trial of medium chain triglyceride-supplemented ketogenic diet in people with Parkinson's disease.BMC neurology · 2024Trial
- Ketone Supplementation Dampens Subjective and Objective Responses to Alcohol: Evidence From a Preclinical Rat Study and a Randomized, Cross-Over Trial in Healthy Volunteers.The international journal of neuropsychopharmacology · 2024Trial
- Modulation of Endoplasmic Reticulum Stress via CEBPB: A Potential Molecular Link to Therapeutic Action in Substance Use Disorders.CNS neuroscience & therapeutics · 2026Article
- Reversible alterations of brain acetate metabolism associated with alcohol consumption.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- A ketogenic diet reduces hepatic alcohol metabolism and alcohol consumption in rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Eating a ketogenic diet enhances sensitivity of rats to the effects of methamphetamine, but not dopamine DPharmacology, biochemistry, and behavior · 2025Article
- Acute Supplementation of Beta-Hydroxybutyrate Increases Visual Cortical Excitability in Humans: A Combined Electro-EncephaloGraphy and Magnetic Resonance Spectroscopy Study.The European journal of neuroscience · 2025Article
- Eating a high fat/high carbohydrate diet enhances morphine tolerance, while eating a ketogenic diet mitigates morphine withdrawal in male rats.European journal of pharmacology · 2025Article
- The effects of high fat diet consumption on morphine-induced constipation.Behavioural pharmacology · 2025Article
- Ketone Supplements and Alcohol-Related Responses in Rodents.Addiction biology · 2025Article
- Paradoxical mTORC1-Dependent microRNA-mediated Translation Repression in the Nucleus Accumbens of Male Mice Consuming Alcohol Attenuates Glycolysis.Nature communications · 2025Article
- Review
- A ketogenic diet regulates microglial activation to treat drug addiction.Frontiers in pharmacology · 2025Review
- Molecular Imaging Studies of Alcohol Use Disorder.Current topics in behavioral neurosciences · 2025Review
- Ketogenic diet, adenosine, and dopamine in addiction and psychiatry.Frontiers in nutrition · 2025Review
- Reduced brain network segregation in alcohol use disorder: Associations with neurocognition.Addiction biology · 2024Article
- Effects of Ketogenic Diet on Increased Ethanol Consumption Induced by Social Stress in Female Mice.Nutrients · 2024Article
- Substance-Induced Psychiatric Disorders, Epigenetic and Microbiome Alterations, and Potential for Therapeutic Interventions.Brain sciences · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 7 institutions in 2 countries.
Corinde E WiersNational Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA. corinde.wiers@pennmedicine.upenn.edu leandro.vendruscolo@nih.gov nvolkow@nida.nih.gov.ORCID 0000-0002-2934-8794
Leandro F VendruscoloNational Institute on Drug Abuse, Baltimore, MD 21224, USA. corinde.wiers@pennmedicine.upenn.edu leandro.vendruscolo@nih.gov nvolkow@nida.nih.gov.ORCID 0000-0002-8829-8627
Jan-Willem van der VeenNational Institute of Mental Health, Bethesda, MD 20892, USA.ORCID 0000-0001-8642-1831
Peter ManzaNational Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA.
Ehsan Shokri-KojoriNational Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA.ORCID 0000-0001-6846-3173
Danielle S KrollNational Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA.
Dana E FeldmanNational Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA.
Katherine L McPhersonNational Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA.ORCID 0000-0002-6606-2410
Catherine L BieseckerNational Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA.
Rui ZhangNational Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA.
Kimberly HermanNational Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA.ORCID 0000-0001-5750-3328
Sophie K ElvigNational Institute on Drug Abuse, Baltimore, MD 21224, USA.ORCID 0000-0002-1049-1523
Janaina C M VendruscoloNational Institute on Drug Abuse, Baltimore, MD 21224, USA.
Sara A TurnerClinical Center Nutrition Department, National Institutes of Health, Bethesda, MD 20892, USA.
Shanna YangClinical Center Nutrition Department, National Institutes of Health, Bethesda, MD 20892, USA.
Melanie SchwandtNational Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA.ORCID 0000-0002-8355-4900
Dardo TomasiNational Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA.
Mackenzie C CervenkaDepartment of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA.ORCID 0000-0002-4760-857X
Anders Fink-JensenPsychiatric Centre Copenhagen, University Hospital of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-7143-1236
Helene BenvenisteDepartment of Anesthesiology, Yale University, New Haven, CT 06519, USA.ORCID 0000-0002-2887-6667
Nancy DiazgranadosNational Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA.ORCID 0000-0002-7415-8455
Gene-Jack WangNational Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA.ORCID 0000-0002-5017-9905
George F KoobNational Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA.
Nora D VolkowNational Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA. corinde.wiers@pennmedicine.upenn.edu leandro.vendruscolo@nih.gov nvolkow@nida.nih.gov.ORCID 0000-0001-6668-0908
National Institute on Alcohol Abuse and Alcoholism · USNational Institute on Drug Abuse · USNational Institutes of Health Clinical Center · USCopenhagen University Hospital · DKJohns Hopkins University · USNational Institute of Mental Health · USYale University · US
Funding
Neurobiology of Substance Abuse and AddictionZIAAA000550 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI VOLKOW, NORA D. · 2009 to 2025
$115.1MYale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MNIAAA Repository/Screening Database Management and ResearchZIAAA000130 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI SCHWANDT, MELANIE · 2017 to 2025
$60.1MNeurobiology of AddictionZIADA000602 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI KOOB, GEORGE · 2019 to 2025
$16.3MMagnetic Resonance Spectroscopy Core FacilityZICMH002894 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI SHEN, JUN · 2009 to 2024
$13.5MKetone ester intervention in alcohol use disorderR00AA026892 · NIAAA · UNIVERSITY OF PENNSYLVANIA · PI WIERS, CORINDE E · 2020 to 2022
$747kNCATS NIH HHS UL1 TR001863NIAAA NIH HHS R00 AA026892
Abstract
Individuals with alcohol use disorder (AUD) show elevated brain metabolism of acetate at the expense of glucose. We hypothesized that a shift in energy substrates during withdrawal may contribute to withdrawal severity and neurotoxicity in AUD and that a ketogenic diet (KD) may mitigate these effects. We found that inpatients with AUD randomized to receive KD (
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LicenceCC BY-NC
Read underepoch 390
Registered trials
NCT03255031ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.