Evidence map›Paper›PMID 33837052›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021

Ventral Pallidum GABA Neurons Mediate Motivation Underlying Risky Choice.

Mitchell R Farrell, Jeanine Sandra D Esteban, Lauren Faget, Stan B Floresco, Thomas S Hnasko, Stephen V Mahler

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 56 citations in OpenAlex.

  1. Histamine HMolecular psychiatry · 2026
    Article
  2. Unpacking Ventral Pallidum GABA Neuron Contributions to Opioid Drug Reward in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  3. Article
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  5. Most Ventral Pallidal Cholinergic Neurons Are Bursting Basal Forebrain Cholinergic Neurons with Mesocorticolimbic Connectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  6. Ventral pallidal perineuronal nets regulate opioid relapse.bioRxiv : the preprint server for biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Mitchell R FarrellDepartment of Neurobiology & Behavior, University of California, Irvine, California 92697 mrfarrel@uci.edu.
Jeanine Sandra D EstebanDepartment of Neurobiology & Behavior, University of California, Irvine, California 92697.
Lauren FagetDepartment of Neurosciences, University of California, San Diego, California 92093.
Stan B FlorescoDepartment of Psychology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.ORCID 0000-0002-5633-243X
Thomas S HnaskoDepartment of Neurosciences, University of California, San Diego, California 92093.ORCID 0000-0001-6176-8513
Stephen V MahlerDepartment of Neurobiology & Behavior, University of California, Irvine, California 92697.ORCID 0000-0002-8698-0905
University of California, Irvine · USUniversity of California San Diego · USUniversity of British Columbia · CA

Funding

Impact of Cannabinoid Across the Lifespan (ICAL)P50DA044118 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Christine M Gall · 2018 to 2026
$18.2M
Role of novel VTA neurons in addiction-related behaviorsR01DA036612 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Thomas Hnasko · 2014 to 2026
$5.6M
Epilepsy Research Training ProgramT32NS045540 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Tallie Z. Baram, Robert F Hunt · 2003 to 2026
$4.9M
Role of Ventral Pallidum Projection to VTA in Reinstatement of Cocaine SeekingR00DA035251 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI MAHLER, STEPHEN VINCENT · 2015 to 2017
$756k
Role of functional and anatomical heterogeneity in ventral pallidum circuits underlying behavioral reinforcementR21MH118748 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HNASKO, THOMAS · 2018 to 2019
$433k
Ventral Pallidum Circuits in Motivation, Risky Decision Making, and Opioid AddictionF99NS120641 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI FARRELL, MITCHELL · 2020 to 2021
$85k
Ventral Pallidum GABA Circuits in Risky Decision MakingF31DA048578 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI FARRELL, MITCHELL · 2019 to 2020
$55k
NIDA NIH HHS F31 DA048578NIDA NIH HHS P50 DA044118NIDA NIH HHS R00 DA035251NIDA NIH HHS R01 DA036612NIMH NIH HHS R21 MH118748NINDS NIH HHS F99 NS120641NINDS NIH HHS T32 NS045540
6 · The paper itself

Abstract

Pursuing rewards while avoiding danger is an essential function of any nervous system. Here, we examine a new mechanism helping rats negotiate the balance between risk and reward when making high-stakes decisions. Specifically, we focus on GABA neurons within an emerging mesolimbic circuit nexus: the ventral pallidum (VP). These neurons play a distinct role from other VP neurons in simple motivated behaviors in mice, but their role in more complex motivated behaviors is unknown. Here, we interrogate the behavioral functions of VP

Indexed as

AnimalsBasal ForebrainChoice BehaviorFemaleGABAergic NeuronsMaleMotivationRatsRats, TransgenicRewardaddictionaversionavoidancechemogeneticsrewardultrasonic vocalizations

Identifiers

PMID33837052
PMCPMC8152612
OpenAlexW3139729906

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.