Evidence map›Paper›PMID 33837019›Full record

ArticleApplied and environmental microbiology2021

Tobramycin Adaptation Enhances Policing of Social Cheaters in Pseudomonas aeruginosa.

Rhea G Abisado, John H Kimbrough, Brielle M McKee, Vaughn D Craddock, Nicole E Smalley, Ajai A Dandekar, Josephine R Chandler

Open access · greenAbstract read
In one paragraph

Article in Applied and environmental microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Inactivation of MexT inJournal of bacteriology · 2026
    Article
  2. Article
  3. Review
  4. Inactivation of MexT inbioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Quorum-sensing regulation of phenazine production heightensAntimicrobial agents and chemotherapy · 2024
    Article
  7. Article
  8. Article
  9. Tolfenpyrad displaysMicrobiology spectrum · 2023
    Article
  10. Article
  11. Article
  12. TheFrontiers in microbiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Rhea G AbisadoDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
John H KimbroughDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
Brielle M McKeeDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
Vaughn D CraddockDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
Nicole E SmalleyDepartment of Microbiology, University of Washington School of Medicine, Seattle, Washington, USA.
Ajai A DandekarDepartment of Microbiology, University of Washington School of Medicine, Seattle, Washington, USA.
Josephine R ChandlerDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
University of Kansas · USUniversity of Washington · US

Funding

Mentoring CoreP20GM103418 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Douglas E Wright · 2012 to 2026
$63.0M
Synthetic Chemical Biology CoreP20GM113117 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI OROZCO, ROBIN C. · 2016 to 2025
$23.9M
Understanding the mechanobiology of stem cells in a microengineered 3D cardiac tissue environment with cardiomyopathyP20GM103638 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI LUNTE, SUSAN M · 2012 to 2021
$22.1M
RESEARCH TRAINING IN INFECTIOUS DISEASEST32AI007343 · NIAID · UNIVERSITY OF IOWA · PI STAPLETON, JACK T. · 1988 to 2024
$5.0M
Quorum sensing evolution and function in mixed bacterial communitiesR35GM133572 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI CHANDLER, JOSEPHINE R · 2019 to 2024
$2.1M
Pseudomonas aeruginosa quorum sensingR01GM125714 · NIGMS · UNIVERSITY OF WASHINGTON · PI DANDEKAR, AJAI · 2018 to 2022
$1.6M
NIAID NIH HHS T32 AI007343NIGMS NIH HHS P20 GM103418NIGMS NIH HHS P20 GM103638NIGMS NIH HHS P20 GM113117NIGMS NIH HHS R01 GM125714NIGMS NIH HHS R35 GM133572
6 · The paper itself

Abstract

The Pseudomonas aeruginosa LasR-LasI (LasR-I) quorum sensing system regulates secreted proteases that can be exploited by cheaters, such as quorum sensing receptor-defective (

Indexed as

Drug Resistance, BacterialQuorum SensingAnti-Bacterial AgentsBacterial ProteinsPseudomonas aeruginosaPyocyanineTobramycinTrans-ActivatorsAnti-Bacterial AgentsBacterial ProteinsLasR protein, Pseudomonas aeruginosaPyocyanineTobramycinTrans-ActivatorscooperationPseudomonas aeruginosaquorum sensing

Identifiers

PMID33837019
PMCPMC8174604
OpenAlexW3146627709

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.