Evidence map›Paper›PMID 33836922›Full record

ArticleSchizophrenia research2022

Development of a computerized adaptive diagnostic screening tool for psychosis.

Robert D Gibbons, Ishanu Chattopadhyay, Herbert Y Meltzer, John M Kane, Daniel Guinart

Abstract read
In one paragraph

Article in Schizophrenia research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Optimizing Symptom Surveys with Machine Learning to Predict PTSD One Year Post-trauma....IEEE...International Conference on Connected Health: Applications, Systems and Engineering Technologies. IEEE International Conference on Connected Health: Applications, Systems and Engineering Technologies · 2026
    Article
  4. Article
  5. A novel CAT method for QoL screening: proof-of-principle study with comparisons to standard methods.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Robert D GibbonsCenter for Health Statistics, Department of Medicine, the Committee on Quantitative Methods, University of Chicago, Chicago, IL, USA; Departments of Public Health Sciences (Biostatistics), Psychiatry, Comparative Human Development, University of Chicago, Chicago, IL, USA. Electronic address: rdg@uchicago.edu.
Ishanu ChattopadhyayCenter for Health Statistics, Department of Medicine, the Committee on Quantitative Methods, University of Chicago, Chicago, IL, USA.
Herbert Y MeltzerNorthwestern University, Department of Psychiatry, Chicago, IL, USA.
John M KaneThe Zucker Hillside Hospital, Department of Psychiatry Research, New York, USA; Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, NY, USA; The Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Manhasset, NY, USA.
Daniel GuinartThe Zucker Hillside Hospital, Department of Psychiatry Research, New York, USA; Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, NY, USA; The Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Manhasset, NY, USA.

Funding

Bipolar & Schizophrenia Consortium for Parsing Intermediate PhenotypesR01MH077851 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI TAMMINGA, CAROL A · 2007 to 2019
$7.8M
NIMH NIH HHS R01 MH077851
6 · The paper itself

Abstract

We develop a two-stage diagnostic classification system for psychotic disorders using an extremely randomized trees machine learning algorithm. Item bank was developed from clinician-rated items drawn from an inpatient and outpatient sample. In stage 1, we differentiate schizophrenia and schizoaffective disorder from depression and bipolar disorder (with psychosis). In stage 2 we differentiate schizophrenia from schizoaffective disorder. Out of sample classification accuracy, determined by area under the receiver operator characteristic (ROC) curve, was outstanding for stage 1 (Area under the ROC curve (AUC) = 0.93, 95% confidence interval (CI) = 0.89, 0.94), and excellent for stage 2 (AUC = 0.86, 95% CI = 0.83, 0.88). This is achieved based on an average of 5 items for stage 1 and an average of 6 items for stage 2, out of a bank of 73 previously validated items.

Indexed as

Bipolar DisorderPsychotic DisordersSchizophreniaHumansMachine LearningOutpatientsComputerized adaptive diagnosisExtremely randomized decision treesMeasurementPsychosis

Identifiers

PMID33836922
PMCPMC8492780

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.