ArticleReproductive biology and endocrinology : RB&E2021
Thin endometrium is associated with the risk of hypertensive disorders of pregnancy in fresh IVF/ICSI embryo transfer cycles: a retrospective cohort study of 9,266 singleton births.
Article in Reproductive biology and endocrinology : RB&E, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- A Systematic Review on Biomarkers for Gestational Diabetes Mellitus Detection in Pregnancies Conceived Using Assisted Reproductive Technology: Current Trends and Future Directions.International journal of molecular sciences · 2025Pooled it
- Effect of endometrial thickness on obstetric and neonatal outcomes in assisted reproduction: a systematic review and meta-analysis.Reproductive biology and endocrinology : RB&E · 2023Pooled it
- The Effect of Endometrial Thickness on Pregnancy, Maternal, and Perinatal Outcomes of Women in Fresh Cycles After IVF/ICSI: A Systematic Review and Meta-Analysis.Frontiers in endocrinology · 2021Pooled it
- Organoids: Current Applications and Future Directions.MedComm · 2026Review
- Article
- How endometrial thickness affects pregnancy and perinatal outcomes: a retrospective study of 16,566 frozen-thawed single blastocyst transfer cycles.Reproductive biology and endocrinology : RB&E · 2026Article
- A standardized protocol for autologous stromal vascular fraction therapy in refractory thin endometrium and a prospective single-arm clinical study.Stem cell research & therapy · 2026Article
- Endometrial thickness is not a risk factor for hypertensive disorders of pregnancy after IVF treatment in women with male-factor infertility.Frontiers in endocrinology · 2026Article
- GM-CSF improves the receptivity of thin endometrium by promoting glandular and stromal cell proliferation in mice and humans.Cell death discovery · 2025Article
- Advances in the Pathophysiology of Thin Endometrium.Reproductive sciences (Thousand Oaks, Calif.) · 2025Review
- Endometrial hypoperfusion: the missing link in refractory thin endometrium.Frontiers in reproductive health · 2025Review
- Is there a relationship between morphokinetic parameters and obstetrical complications? An analysis of singleton live births after single fresh embryo transfer.BMC pregnancy and childbirth · 2024Article
- The gestational age-specific difference in birthweight between singletons born after fresh and frozen embryo transfer: A cohort study.Acta obstetricia et gynecologica Scandinavica · 2023Article
- Endometrial thickness and early pregnancy complications after frozen-thawed embryo transfers.Frontiers in endocrinology · 2023Article
- Fibroblast growth factor 1 ameliorates thin endometrium in rats through activation of the autophagic pathway.Frontiers in pharmacology · 2023Article
- The thicker the endometrium, the better the neonatal outcomes?Human reproduction open · 2023Article
- Impaired receptivity of thin endometrium: therapeutic potential of mesenchymal stem cells.Frontiers in endocrinology · 2023Review
- Endometrial thickness is an independent risk factor of hypertensive disorders of pregnancy: a retrospective study of 13,458 patients in frozen-thawed embryo transfers.Reproductive biology and endocrinology : RB&E · 2022Article
- "Double Frozen Transfer" Could Influence the Perinatal and Children's Growth: A Nested Case-Control Study of 6705 Live Birth Cycles.Frontiers in endocrinology · 2022Article
- Association of Polycystic Ovary Syndrome Phenotypes With Adverse Pregnancy Outcomes AfterFrontiers in endocrinology · 2022Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThin endometrial thickness (EMT) has been suggested to be associated with reduced incidence of pregnancy rate after in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment, but the effect of thin endometrium on obstetric outcome is less investigated. This study aims to determine whether EMT affects the incidence of obstetric complications in fresh IVF/ICSI-embryo transfer (ET) cycles.
methodsWe conducted a retrospective cohort study collecting a total of 9266 women who had singleton livebirths after fresh IVF/ICSI-ET treatment cycles at the Center for Reproductive Medicine Affiliated to Shandong University between January 2014 and December 2018. The women were divided into three groups according to the EMT: 544 women with an EMT ≤8 mm, 6234 with an EMT > 8-12 mm, and 2488 with an EMT > 12 mm. The primary outcomes were the incidence of obstetric complications including hypertensive disorders of pregnancy (HDP), gestational diabetes mellitus (GDM), placental abruption, placenta previa, postpartum hemorrhage (PPH) and cesarean section. Multivariable logistic regression analysis was performed to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) for associations between the EMT measured on the day of human chorionic gonadotropin (HCG) trigger and the risk of the outcomes of interest.
resultsThe HDP incidence rate of pregnant women was highest in EMT ≤ 8 mm group and significantly higher than those in EMT from > 8-12 mm and EMT > 12 mm group, respectively (6.8% versus 3.6 and 3.5%, respectively; P = 0.001). After adjustment for confounding variables by multivariate logistic regression analysis, a thin EMT was still statistically significant associated with an increased risk of HDP. Compared with women with an EMT > 8-12 mm, women with an EMT ≤8 mm had an increased risk of HDP (aOR = 1.853, 95% CI 1.281-2.679, P = 0.001).
conclusionA thin endometrium (≤8 mm) was found to be associated with an increased risk of HDP after adjustment for confounding variables, indicating that the thin endometrium itself is a risk factor for HDP. Obstetricians should remain aware of the possibility of HDP when women with a thin EMT achieve pregnancy through fresh IVF/ICSI-ET treatment cycles.
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