ArticleJournal of foot and ankle research2021
Rates and risk factors for amputation in people with diabetes in Japan: a historical cohort study using a nationwide claims database.
Article in Journal of foot and ankle research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Does preoperative muscle biopsy predict the outcome of lower extremity amputation in diabetic patients? a prospective observational study.BMC musculoskeletal disorders · 2025Observational
- Pyridine Derivatives: A Comprehensive Review of Their Potential as Anti-Diabetic Agents.Medicinal chemistry (Shariqah (United Arab Emirates)) · 2025Review
- Longitudinal Study of Quality of Life in Individuals with Lower Limb Amputation.Progress in rehabilitation medicine · 2025Article
- Prognostic Factor of Lower Limb Amputation among Diabetic Foot Ulcer Patients in North-East Peninsular Malaysia.International journal of environmental research and public health · 2022Article
- Temporal trends in patients with peripheral artery disease influenced by diabetes mellitus in Germany.Journal of diabetes · 2022Article
- Incidence of interventions for diabetic retinopathy and serious lower-limb complications and its related factors in patients with type 2 diabetes using a real-world large claims database.Diabetology international · 2022Article
- Diabetes Mellitus and Its Impact on Patient-Profile and In-Hospital Outcomes in Peripheral Artery Disease.Journal of clinical medicine · 2021Article
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Authors and funding
11 authors.
Funding
Abstract
backgroundThe prevalence of diabetes is rising, and diabetes develops at a younger age in East Asia. Although lower limb amputation negatively affects quality of life and increases the risk of cardiovascular events, little is known about the rates and predictors of amputation among persons with diabetes from young adults to those in the "young-old" category (50-72 y).
methodsWe analyzed data from a nationwide claims database in Japan accumulated from 2008 to 2016 involving 17,288 people with diabetes aged 18-72 y (mean age 50.2 y, HbA1c 7.2%). Amputation occurrence was determined according to information from the claims database. Cox regression model identified variables related to lower limb amputation.
resultsThe mean follow-up time was 5.3 years, during which time 16 amputations occurred (0.17/1000 person-years). Multivariate Cox regression analysis showed that age (hazard ratio [HR] 1.09 [95% confidence intervals] 1.02-1.16, p = 0.01) and HbA1c (HR 1.46 [1.17-1.81], p < 0.01) were independently associated with amputations. Compared with those aged < 60 years with HbA1c < 8.0%, the HR for amputation was 27.81 (6.54-118.23) in those aged ≥60 years and HbA1c ≥8.0%.
conclusionsAge and HbA1c were associated with amputations among diabetic individuals, and the rates of amputation were significantly greater in those ≥60 years old and with HbA1c ≥8.0%.
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