ArticleBMC complementary medicine and therapies2021
Phytochemical analysis of medicinal plants of Nepal and their antibacterial and antibiofilm activities against uropathogenic Escherichia coli.
Article in BMC complementary medicine and therapies, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 61 citations in OpenAlex.
- The interactions of natural compounds with Escherichia coli motility, attachment, communication systems, and mature biofilm.Archives of microbiology · 2025Review
- Cranberry-Derived Phenolic Compounds Contribute to the Inhibition of FimH-MediatedAntibiotics (Basel, Switzerland) · 2025Article
- High-throughput combination assay for studying biofilm formation of uropathogenic Escherichia coli.Archives of microbiology · 2024Article
- Elimination of detached Listeria monocytogenes from the biofilm on stainless steel surfaces during milk and cheese processing using natural plant extracts.Scientific reports · 2024Article
- Antimicrobial and Antibiofilm Activity of Monolaurin against Methicillin-ResistantInternational journal of microbiology · 2024Article
- Endophytic Fungi Isolated fromPlants (Basel, Switzerland) · 2023Article
- Toxicity test of flavonoid compounds from the leaves ofVeterinary world · 2022Article
- Article
- Antibacterial and antibiofilm activity of Lagotis brachystachya extract against extended-spectrum β-lactamases-producing Escherichia coli from broiler chickens.Poultry science · 2022Article
- Phytochemical Analysis and Antioxidant and Antidiabetic Activities of Extracts fromAdvances in pharmacological and pharmaceutical sciences · 2022Article
- An assessment of the evidence for antibacterial activity of stinging nettle (Access microbiology · 2022Article
- Fatty Acid Composition, Antioxidant, andFrontiers in nutrition · 2021Article
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Authors and funding
8 authors at 1 institution in 1 country.
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Abstract
backgroundA biofilm is an extracellular polymeric substance (EPS) composed of polysaccharides, proteins, nucleic acids, and lipids that impede antibiotics and immune cells, thus providing a shielded environment for bacterial growth. Due to biofilm formation, some microbes can show up to 1000 fold increased resistance towards the antibiotics than the normal planktonic forms. The study was conducted to screen the crude extracts of medicinal plants used in Nepal for their in vitro antibiofilm activities.
methodsTotal phenolic and total flavonoid contents were determined by using a Folin-Ciocalteau reagent and aluminium trichloride method, respectively. Resazurin assay was used to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The initial antibiofilm activities and their inhibitory concentration (IC
resultsOut of 25 different plant extracts were used for the study, methanolic extracts of 20 plants showed a biofilm inhibition activity against five different strong biofilm producing Escherichia coli strains. Calotropis gigantea exhibited inhibition against all five different E. coli strains with IC
conclusionExtracts of C. gigantea, E. prostrata, P. persica, U. parviflora, and O. tenuifolium showed antibacterial as well as antibiofilm activity against pathogenic and strong biofilm producing E. coli. Thus, extracts or the pure compound from these medicinal plants could be used as antibiotics in the future.
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