ArticleBMC genomics2021
Transcriptomic, proteomic and ultrastructural studies on salinity-tolerant Aedes aegypti in the context of rising sea levels and arboviral disease epidemiology.
Article in BMC genomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Introgression Shapes Genetic Variation Associated With Humid Environments in Aedes aegypti Mosquitoes From Saudi Arabia.Molecular ecology · 2026Article
- Resistance to pyrethroids in Aedes aegypti: Insights into transcriptomic response to different insecticide concentrations.PLoS neglected tropical diseases · 2026Article
- Amino Acid Substitutions in the NaEcological entomology · 2026Article
- Investigating genetic differentiation between brackish and fresh water collections of the arboviral vector Aedes aegypti.Parasites & vectors · 2026Article
- Amino Acid Substitutions in the NabioRxiv : the preprint server for biology · 2025Article
- Genome Structural Variants Shape Adaptive Success of an Invasive Urban Malaria Vector Anopheles stephensi.Molecular biology and evolution · 2025Article
- Assessing the global dengue burden: Incidence, mortality, and disability trends over three decades.PLoS neglected tropical diseases · 2025Observational
- Identification of Candidate Male-Reproduction-Related Genes from the Testis and Androgenic Gland ofInternational journal of molecular sciences · 2024Article
- Voltage-gated ion channels are expressed in the Malpighian tubules and anal papillae of the yellow fever mosquito (Aedes aegypti), and may regulate ion transport during salt and water imbalance.The Journal of experimental biology · 2024Article
- Resistance to the larvicide temephos and altered egg and larval surfaces characterize salinity-tolerant Aedes aegypti.Scientific reports · 2023Article
- Increasing Dengue Burden and Severe Dengue Risk in Bangladesh: An Overview.Tropical medicine and infectious disease · 2023Review
- The Bright Side of the Tiger: Autofluorescence Patterns inMolecules (Basel, Switzerland) · 2022Article
- Expansive and Diverse Phenotypic Landscape of Field Aedes aegypti (Diptera: Culicidae) Larvae with Differential Susceptibility to Temephos: Beyond Metabolic Detoxification.Journal of medical entomology · 2022Article
- Regional Variation in Dengue Virus Serotypes in Sri Lanka and Its Clinical and Epidemiological Relevance.Diagnostics (Basel, Switzerland) · 2021Article
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Authors and funding
12 authors at 4 institutions in 4 countries.
Funding
Abstract
backgroundAedes aegypti mosquito, the principal global vector of arboviral diseases, lays eggs and undergoes larval and pupal development to become adult mosquitoes in fresh water (FW). It has recently been observed to develop in coastal brackish water (BW) habitats of up to 50% sea water, and such salinity tolerance shown to be an inheritable trait. Genomics of salinity tolerance in Ae. aegypti has not been previously studied, but it is of fundamental biological interest and important for controlling arboviral diseases in the context of rising sea levels increasing coastal ground water salinity.
resultsBW- and FW-Ae. aegypti were compared by RNA-seq analysis on the gut, anal papillae and rest of the carcass in fourth instar larvae (L4), proteomics of cuticles shed when L4 metamorphose into pupae, and transmission electron microscopy of cuticles in L4 and adults. Genes for specific cuticle proteins, signalling proteins, moulting hormone-related proteins, membrane transporters, enzymes involved in cuticle metabolism, and cytochrome P450 showed different mRNA levels in BW and FW L4 tissues. The salinity-tolerant Ae. aegypti were also characterized by altered L4 cuticle proteomics and changes in cuticle ultrastructure of L4 and adults.
conclusionsThe findings provide new information on molecular and ultrastructural changes associated with salinity adaptation in FW mosquitoes. Changes in cuticles of larvae and adults of salinity-tolerant Ae. aegypti are expected to reduce the efficacy of insecticides used for controlling arboviral diseases. Expansion of coastal BW habitats and their neglect for control measures facilitates the spread of salinity-tolerant Ae. aegypti and genes for salinity tolerance. The transmission of arboviral diseases can therefore be amplified in multiple ways by salinity-tolerant Ae. aegypti and requires appropriate mitigating measures. The findings in Ae. aegypti have attendant implications for the development of salinity tolerance in other fresh water mosquito vectors and the diseases they transmit.
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