Evidence map›Paper›PMID 33836615›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

A synthetic 5,3-cross-link in the cell wall of rod-shaped Gram-positive bacteria.

David A Dik, Nan Zhang, Emily J Sturgell, Brittany B Sanchez, Jason S Chen, Bill Webb, Kimberly G Vanderpool, Peter G Schultz

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

David A DikDepartment of Chemistry, Scripps Research, La Jolla, CA 92037.ORCID 0000-0002-4700-3837
Nan ZhangDepartment of Chemistry, Scripps Research, La Jolla, CA 92037.
Emily J SturgellAutomated Synthesis Facility, Scripps Research, La Jolla, CA 92037.
Brittany B SanchezAutomated Synthesis Facility, Scripps Research, La Jolla, CA 92037.
Jason S ChenAutomated Synthesis Facility, Scripps Research, La Jolla, CA 92037.
Bill WebbCenter for Metabolomics and Mass Spectrometry, Scripps Research, La Jolla, CA 92037.
Kimberly G VanderpoolCore Microscopy Facility, Scripps Research, La Jolla, CA 92037.
Peter G SchultzDepartment of Chemistry, Scripps Research, La Jolla, CA 92037; schultz@scripps.edu.ORCID 0000-0003-3188-1202
Scripps Institution of Oceanography · USScripps Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gram-positive bacteria assemble a multilayered cell wall that provides tensile strength to the cell. The cell wall is composed of glycan strands cross-linked by nonribosomally synthesized peptide stems. Herein, we modify the peptide stems of the Gram-positive bacterium

Indexed as

Amino AcidsBacillus subtilisCell WallGram-Negative BacteriaGram-Positive RodsPeptidoglycanPeptidyl TransferasesPhenotypeAmino AcidsPeptidoglycanPeptidyl Transferasesbacteriacell wallsynthetic cross-linkstranspeptidases

Identifiers

PMID33836615
PMCPMC7980369
OpenAlexW3135708708

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.