Evidence map›Paper›PMID 33836592›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Cryo-EM structure and kinetics reveal electron transfer by 2D diffusion of cytochrome

Agnes Moe, Justin Di Trani, John L Rubinstein, Peter Brzezinski

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 60 citations in OpenAlex.

  1. Functional Reconstitution of Mitochondrial Respiratory Supercomplexes.Journal of visualized experiments : JoVE · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Quantum biology: From mechanisms to medicine.Clinical and translational medicine · 2026
    Review
  6. Article
  7. The complexities of respiratory chain biogenesis and maintenance in yeast mitochondria.Protein science : a publication of the Protein Society · 2026
    Review
  8. Article
  9. Article
  10. BN-PAGE of Ustilago maydis Respiratory Complexes.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  11. Article
  12. Article
  13. Insertion of the FeFEBS letters · 2025
    Article
  14. HThe Journal of biological chemistry · 2025
    Article
  15. Article
  16. Review
  17. Article
  18. SCAF1 drives the compositional diversity of mammalian respirasomes.Nature structural & molecular biology · 2024
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Agnes MoeDepartment of Biochemistry and Biophysics, The Arrhenius Laboratories for Natural Sciences, Stockholm University, SE-106 91 Stockholm, Sweden.ORCID 0000-0002-3328-763X
Justin Di TraniMolecular Medicine program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
John L RubinsteinMolecular Medicine program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; john.rubinstein@utoronto.ca peterb@dbb.su.se.ORCID 0000-0003-0566-2209
Peter BrzezinskiDepartment of Biochemistry and Biophysics, The Arrhenius Laboratories for Natural Sciences, Stockholm University, SE-106 91 Stockholm, Sweden; john.rubinstein@utoronto.ca peterb@dbb.su.se.ORCID 0000-0003-3860-4988
Stockholm University · SEHospital for Sick Children · CAUniversity of Toronto · CA

Funding

Resource for Biocomputing Visualization and InformaticsP41GM103311 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2012 to 2017
$8.2M
CIHR PJT162186NIGMS NIH HHS P41 GM103311
6 · The paper itself

Abstract

Energy conversion in aerobic organisms involves an electron current from low-potential donors, such as NADH and succinate, to dioxygen through the membrane-bound respiratory chain. Electron transfer is coupled to transmembrane proton transport, which maintains the electrochemical proton gradient used to produce ATP and drive other cellular processes. Electrons are transferred from respiratory complexes III to IV (CIII and CIV) by water-soluble cytochrome (cyt.)

Indexed as

Cryoelectron MicroscopyCytochromes cElectron TransportElectron Transport Complex IIIElectron Transport Complex IVKineticsMitochondriaModels, MolecularSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsCytochromes cElectron Transport Complex IIIElectron Transport Complex IVSaccharomyces cerevisiae Proteinsbioenergeticscytochrome bc1cytochrome c oxidaseelectron transfermitochondria

Identifiers

PMID33836592
PMCPMC7980474
OpenAlexW3135060487

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.