Evidence map›Paper›PMID 33836562›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Decidual cell FKBP51-progesterone receptor binding mediates maternal stress-induced preterm birth.

Ozlem Guzeloglu-Kayisli, Nihan Semerci, Xiaofang Guo, Kellie Larsen, Asli Ozmen, Sefa Arlier, Duygu Mutluay, Chinedu Nwabuobi, Bradley Sipe, Irina Buhimschi and 4 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 42 citations in OpenAlex.

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  6. Stress-induced developmental plasticity and spontaneous preterm birth: A justice-oriented eco-evo-devo review.European journal of obstetrics & gynecology and reproductive biology: X · 2025
    Review
  7. Depletion ofInternational journal of molecular sciences · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Ozlem Guzeloglu-KayisliDepartment of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612; ozlem2@usf.edu cjlockwood@usf.edu.ORCID 0000-0001-5448-917X
Nihan SemerciDepartment of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612.ORCID 0000-0002-4598-8281
Xiaofang GuoDepartment of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612.ORCID 0000-0002-9780-6339
Kellie LarsenDepartment of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612.ORCID 0000-0002-1650-6773
Asli OzmenDepartment of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612.ORCID 0000-0002-2024-6249
Sefa ArlierDepartment of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612.ORCID 0000-0002-0019-8403
Duygu MutluayDepartment of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612.ORCID 0000-0003-3286-130X
Chinedu NwabuobiDepartment of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612.
Bradley SipeDepartment of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612.
Irina BuhimschiDepartment of Obstetrics and Gynecology, University of Illinois College of Medicine, Chicago, IL 60612.
Catalin BuhimschiDepartment of Obstetrics and Gynecology, University of Illinois College of Medicine, Chicago, IL 60612.
Frederick SchatzDepartment of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612.
Umit A KayisliDepartment of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612.ORCID 0000-0002-0379-2168
Charles J LockwoodDepartment of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612; ozlem2@usf.edu cjlockwood@usf.edu.ORCID 0000-0002-7765-4999
University of South Florida · USUniversity of Illinois Urbana-Champaign · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Depression and posttraumatic stress disorder increase the risk of idiopathic preterm birth (iPTB); however, the exact molecular mechanism is unknown. Depression and stress-related disorders are linked to increased FK506-binding protein 51 (FKBP51) expression levels in the brain and/or

Indexed as

Premature BirthStress, PhysiologicalAnimalsFemaleMiceModels, AnimalPregnancyProtein BindingReceptors, ProgesteroneRNA, MessengerTacrolimus Binding Protein 5Tacrolimus Binding ProteinsReceptors, ProgesteroneRNA, MessengerTacrolimus Binding Protein 5Tacrolimus Binding Proteinsdecidual cellsFKBP51maternal stresspreterm birthprogesterone receptor

Identifiers

PMID33836562
PMCPMC7980401
OpenAlexW3133733459

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.