ArticleProceedings of the National Academy of Sciences of the United States of America2021
Quadruple ultrasound, photoacoustic, optical coherence, and fluorescence fusion imaging with a transparent ultrasound transducer.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 1 of them a synthesis that pooled it.
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Who cites it
97 citing papers in PubMed, 1 synthesis or guideline pooled it, 181 citations in OpenAlex.
- Photoacoustic imaging for cutaneous melanoma assessment: a comprehensive review.Journal of biomedical optics · 2024Pooled it
- Article
- Photoacoustic and ultrasound Imaging of placental functions in gestational diabetes: From diagnosis to precision interventions.Photoacoustics · 2026Review
- Advanced methods of wearable ultrasound and photoacoustic imaging devices: A review.Photoacoustics · 2026Article
- Electrically switchable dual-focus metalens for depth-extended in vivo photoacoustic imaging of ophthalmic vascular disease.Light, science & applications · 2026Article
- A Label-Free Ultraviolet Photoacoustic Microscopy Enables Nuclear Imaging and Toxicity Assessment in an Intact Brain Organoid.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Longitudinal three-dimensional photoacoustic imaging reveals hyperoxic perilesional microvasculature associated with keloid recurrence.Photoacoustics · 2026Article
- Activatable smart contrast agents for photoacoustic imaging.Smart molecules : open access · 2026Review
- Fabrication of optically transparent ultrasound transducers to integrate light and sound in multimodal biomedical systems.Nature protocols · 2026Review
- Fully integrated photoacoustic microscopy for multi-scale and longitudinal imaging in translational biomedical applications.Biomedical optics express · 2026Article
- Photoacoustic microscopy reveals deep angiogenic responses in 3D bioprinted tumor-vessel models.Microsystems & nanoengineering · 2026Article
- Photoacoustic Microscopy for Multiscale Biological System Visualization and Clinical Translation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- From light to sound: Seeing and hearing the placenta in health and disease.Science advances · 2026Review
- Development of a Dual Photoacoustic-Ultrasound Imaging System: Current Status and Future Perspectives.Sensors (Basel, Switzerland) · 2026Review
- Potential of photoacoustic imaging for assessing tumor perfusion in intraocular tumors and high-resolution choroidal microvascular imaging: from technical advances to clinical translation.Frontiers in oncology · 2026Review
- A handheld photoacoustic microscopic probe integrating a transparent ultrasound transducer and a fiber scanner.Nature communications · 2025Article
- A three-dimensional photoacoustic and ultrasound automated breast volume scanner (PAUS-ABVS) for breast cancer patients.Science advances · 2025Article
- Rapid cancer diagnosis using deep learning-powered label-free subcellular-resolution photoacoustic histology.Science advances · 2025Article
- 3D multiparametric ultrasound imaging of steatotic liver disease in a study with male rats.Nature communications · 2025Article
- Clinical ultrasound, photoacoustic, and fluorescence image-guided lymphovenous anastomosis microsurgery via a transparent ultrasound transducer array.Nature communications · 2025Article
37 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
17 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ultrasound and optical imagers are used widely in a variety of biological and medical applications. In particular, multimodal implementations combining light and sound have been actively investigated to improve imaging quality. However, the integration of optical sensors with opaque ultrasound transducers suffers from low signal-to-noise ratios, high complexity, and bulky form factors, significantly limiting its applications. Here, we demonstrate a quadruple fusion imaging system using a spherically focused transparent ultrasound transducer that enables seamless integration of ultrasound imaging with photoacoustic imaging, optical coherence tomography, and fluorescence imaging. As a first application, we comprehensively monitored multiparametric responses to chemical and suture injuries in rats' eyes in vivo, such as corneal neovascularization, structural changes, cataracts, and inflammation. As a second application, we successfully performed multimodal imaging of tumors in vivo, visualizing melanomas without using labels and visualizing 4T1 mammary carcinomas using PEGylated gold nanorods. We strongly believe that the seamlessly integrated multimodal system can be used not only in ophthalmology and oncology but also in other healthcare applications with broad impact and interest.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.